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Validity of transhepatic pulp pressure measurements

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Abstract

Cineangiographic studies were undertaken in conjunction with pressure measurements to determine the reliability of transhepatic pulp pressure manometry in assessing portal pressure. Pressure measurements obtained by wedged hepatic vein and/or umbilical-portal vein catheterization were used as a reference. An accurate index to intrasinusoidal pressure was provided when the needle was introduced into the sinusoidal bed and created a vascular “puddle.” Pressures were inaccurate when the needle entered a hepatic venule, the subcapsular space, or a bile duct. Reversible increases in transhepatic pressure were noted with proliferation of sinusoidal-mesenchymal cells attendant to acute liver injury or hyperplasia of the endoplasmic reticulum following administration of drugs that are metabolized in microsomes.

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Authors and Affiliations

  1. Division of Hepatology and Nutrition, Department of Medicine, College of Medicine and Dentistry of New Jersey, 100 Bergen Street, 17103, Newark, NJ

    Willem tenHove MD, Stanislav B. Popovic MD, Maceo M. Howard MD & Carroll M. Leevy MD

  2. Maryland Hospital, Maryland, USA

    Willem tenHove MD, Stanislav B. Popovic MD, Maceo M. Howard MD & Carroll M. Leevy MD

  3. East Orange Veterans Administration Hospital, East Orange, USA

    Willem tenHove MD, Stanislav B. Popovic MD, Maceo M. Howard MD & Carroll M. Leevy MD

Authors
  1. Willem tenHove MD
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  2. Stanislav B. Popovic MD
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  3. Maceo M. Howard MD
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  4. Carroll M. Leevy MD
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tenHove, W., Popovic, S.B., Howard, M.M. et al. Validity of transhepatic pulp pressure measurements. Digest Dis Sci 19, 15–20 (1974). https://doi.org/10.1007/BF01073349

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  • DOI: https://doi.org/10.1007/BF01073349

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