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Significance of serum level of 25-hydroxycholecalciferol in gastrointestinal disease

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Abstract

The serum 25-OHCC concentration was measured in 151 patients in order to evaluate the potential use of this determination in the management of gastrointestinal disorders. Patients with functional bowel disease had lower serum mean 25-OHCC levels than normals. The results were divided into normal (>21 ng/ml), low normal (12–21 ng/ml), and low levels (<21 ng/ml). Two thirds of patients with malabsorption had low serum 25-OHCC. Most patients following jejunoleal bypass surgery for morbid obesity had low levels despite supplemental oral calciferol therapy. In patients with chronic liver disease, cholestasis more than parenchymal cell disease appeared responsible for low serum 25-OHCC levels. Measurement of serum 25-OHCC may be an ancillary screening test for fat malabsorption and in patients with intraluminal bile salt deficiency. Furthermore, repeated measurements may be useful in monitoring therapy with vitamin D products in patients with chronic malabsorption and cholestasis.

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Authors and Affiliations

  1. Department of Medicine College of Physicians and Surgeons, Columbia University, Columbia, USA

    Malcolm S. Schoen MD, John Lindenbaum MD, Martin S. Roginsky MD &  Peter R. Holt MD

  2. Department of Medicine, State of New York Medical School at Stony Brook, Stony Brook, USA

    Malcolm S. Schoen MD, John Lindenbaum MD, Martin S. Roginsky MD &  Peter R. Holt MD

Authors
  1. Malcolm S. Schoen MD
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  2. John Lindenbaum MD
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  3. Martin S. Roginsky MD
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  4. Peter R. Holt MD
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Supported in part by Training Grant AM 05499 and Research Grant AM 13436.

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Schoen, M.S., Lindenbaum, J., Roginsky, M.S. et al. Significance of serum level of 25-hydroxycholecalciferol in gastrointestinal disease. Digest Dis Sci 23, 137–142 (1978). https://doi.org/10.1007/BF01073189

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