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Effect of fat on serum 25-hydroxyvitamin D levels after a single oral dose of vitamin D in young healthy adults: a double-blind randomized placebo-controlled study

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Abstract

Purpose

This double-blind placebo-controlled trial evaluated serum 25-hydroxyvitamin D [25(OH)D] levels after the oral intake of a single dose of cholecalciferol during one of the three meals, containing different amounts of fat or placebo.

Methods and results

Sixty-four healthy medical residents or students of a university hospital in Porto Alegre, latitude 30°S, Brazil, were divided into four groups. Three groups received a single 50,000 IU oral dose of cholecalciferol during a meal containing 0 g (Group 1), 15 g (Group 2) or 30 g (Group 3) of fat, and one group received placebo (Group 4), according to randomization. Serum 25(OH)D, parathyroid hormone, total calcium, albumin, magnesium, and creatinine levels, and urinary calcium, magnesium, and creatinine levels were measured at baseline and after 14 days. Baseline mean serum 25(OH)D levels were low in all groups. Vitamin D given during breakfast increased the mean change of serum 25(OH)D levels, when compared to placebo. Furthermore, the intake of fat with vitamin D increased the mean change of serum 25(OH)D levels.

Conclusion

A single oral dose of vitamin D given with food increased mean serum 25(OH)D levels, after 2 weeks, and the mean increase was larger, when the meal had at least 15 g of fat. These findings can have important implications to oral vitamin D supplementation.

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Acknowledgments

We are grateful to the Fundo de Incentivo à Pesquisa e Eventos of the Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil, and the Conselho Nacional de Pesquisas of Brazil for funding our research and to Roberta Pires Bastos Oliveira for preparing vitamin D and placebo capsules. This work was supported by the Fundo de Incentivo à Pesquisa e Eventos, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil, and the Conselho Nacional de Pesquisas (CNPq), Brazil.

Conflict of interest

All authors state that they have no conflict of interests.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Fabiana Viegas Raimundo, Natália Aydos Marcondes, Gustavo Adolpho Moreira Faulhaber & Tania Weber Furlanetto

  2. Departamento de Nutrição, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil

    Fabiana Viegas Raimundo

  3. Serviço de Medicina Interna, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil

    Maria Augusta Britto Lang, Luciano Scopel & Tania Weber Furlanetto

  4. Faculdade de Medicina: Graduação em Nutrição, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Mirna Griselda Anocibar Araújo

Authors
  1. Fabiana Viegas Raimundo
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  2. Maria Augusta Britto Lang
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  3. Luciano Scopel
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  4. Natália Aydos Marcondes
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  5. Mirna Griselda Anocibar Araújo
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  6. Gustavo Adolpho Moreira Faulhaber
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  7. Tania Weber Furlanetto
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Corresponding author

Correspondence to Gustavo Adolpho Moreira Faulhaber.

Additional information

ClinicalTrials.gov: NCT01519986.

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Raimundo, F.V., Lang, M.A.B., Scopel, L. et al. Effect of fat on serum 25-hydroxyvitamin D levels after a single oral dose of vitamin D in young healthy adults: a double-blind randomized placebo-controlled study. Eur J Nutr 54, 391–396 (2015). https://doi.org/10.1007/s00394-014-0718-8

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  • DOI: https://doi.org/10.1007/s00394-014-0718-8

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