Abstract
Adaptation in the small bowel after resection is associated with increases in crypt cell proliferation and villus height. This paper gives the results of an autoradiographic investigation with [3H]thymidine of epithelial cell migration 60 days after 40% small-bowel resection in the rat. The mean number of cell positions between the crypt-villus junction and the leading labeled cell 30 hr after injection was increased by 19.4% in the resected group (P<0.02). The mean total number of cells per villus column was increased by 27.8% (P<0.002). Migration rate estimated in cell positions per hour was accelerated by 18.9% (P<0.001) after resection. The 8.1% lengthened life span of villus cells was not statistically significant. The increased number of cells per villus column and unaltered life span of villus cells would facilitate functional adaptation. The causal relationship between the larger villus cell population and accelerated migration after resection and increased crypt cell proliferation is unknown.
Similar content being viewed by others
References
Loran MR, Crocker TT: Population dynamics of intestinal epithelia in the rat two months after partial resection of the ileum. J Cell Biol 19:285–291, 1963
Hanson WR, Osborne JW: Epithelial cell kinetics in the small intestine of the rat 60 days after resection of 70 per cent of the ileum and jejunum. Gastroenterology 60:1087–1097, 1971
McDermott FT, Roudnew B: Ileal crypt cell kinetics after 40% small bowel resection: Autoradiographic studies in the rat. Gastroenterology, 70:707–711, 1976
Loran MR, Althausen TL: Cellular proliferation of intestinal epithelia in the rat two months after partial resection of the ileum. J Biophys Biochem Cytol 7:667–671, 1960
Dowling RH, Booth CC: Structural and functional changes following small intestinal resection in the rat. Clin Sci 32:139–149, 1967
Nygaard K: Resection of the small intestine in rats. III. Morphological changes in the intestinal tract. Acta Chir Scand 133:233–248, 1967
Skala I, Hromadkova V, Skala J: Hypertrophy of the small intestine after its partial resection in the rat—size of the mucosal surface. Digestion 2:23–34 (1969)
Weser E, Hernandez MH: Studies of small bowel adaptation after intestinal resection in the rat. Gastroenterology 60:69–75, 1971
McDermott FT, Dalton MK, Galbraith AJ: Ileal epithelial cell migration in acute renal failure. Autoradiographic studies in the mouse. Am J Dig Dis 19:1116–1119, 1974
Galjaard H, Van Der Meer-Fieggen W, Giesen J: Feedback control by functional villus cells on cell proliferation and maturation in intestinal epithelium. Exp Cell Res 73:197–207, 1972
Altmann GG, Enesco M: Cell number as a measure of distribution and renewal of epithelial cells in the small intestine of growing and adult rats. Am J Anat 121:319–336, 1967
Clarke RM: Mucosal architecture and epithelial cell production rate in the small intestine of the albino rat. J Anat 107:519–529, 1970
Clarke RM: A comparison of metaphase arresting agents and tritiated thymidine autoradiography in measurement of the rate of entry of cells into mitosis in the crypts of Lieberkuhn of the rat. Cell Tissue Kinet 4:263–272, 1971
Baker DG, Carsten AL, Hopper AF: The influence of a low environmental temperature on the stem cell population of bone marrow and intestinal mucosa. Cell Tissue Kinet 4:61–68, 1971
Feldman EJ, Peters TJ, McNaughton J, Dowling RH: Adaptation after small bowel resection: Comparison of oral versus intravenous nutrition. Gastroenterology 66:691, 1974 (abstract)
Levine GM, Deren JJ, Steiger E, Zinno R: Role of oral intake in maintenance of gut mass and disaccharide activity. Gastroenterology 67:975–982, 1974
Keren DF, Elliott HL, Brown GD, Yardley JH: Atrophy of villi with hypertrophy and hyperplasia of Paneth cells in isolated (Thiry-Vella) ileal loops in rabbits. Light-microscopic studies. Gastroenterology 68:83–93, 1975
Altmann GG, Leblond CP: Factors influencing villus size in the small intestine of adult rats as revealed by transposition of intestinal segments. Am J Anat 127:15–36, 1970
Altmann GG: Influence of bile and pancreatic secretions on the size of the intestinal villi in the rat. Am J Anat 132:167–178, 1971
Author information
Authors and Affiliations
Additional information
This investigation was supported by the National Health and Medical Research Council.
Rights and permissions
About this article
Cite this article
McDermott, F.T., Roudnew, B. Ileal epithelial cell migration after 40% small-bowel resection. Digest Dis Sci 22, 637–640 (1977). https://doi.org/10.1007/BF01073084
Issue Date:
DOI: https://doi.org/10.1007/BF01073084