Abstract
l-Glutamine given orally at 750 mg/kg significantly reduced the formation of gastric mucosal lesions induced by aspirin at 100 mg/kg at 1, 3, and 7 hours in pylorus-ligated rats.l-Glutamine markedly inhibited the loss of H+ and a corresponding increment of Na+ through the aspirin-damaged mucosal barrier, which suggests inhibition of acid back diffusion as the mechanism of action. In vagotomized rats, the diffusion of H+ from the instilled acid solution into the gastric mucosa and outflux of Na+ from the mucosa into the lumen was so strong that aspirin could not show any acceleration of a back diffusion of H+ in contrast to the aspirin-free group. However,l-Glutamine given with or without aspirin inhibited the back diffusion of H+ instilled into the vagotomized rat stomach.
Similar content being viewed by others
References
Okabe S, Takeuchi, K, Nakamura K, Takagi K: Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat. Jap J Pharmacol 24:363–371, 1974
Takagi K, Takeuchi K, Nakamura K, Morita A, Okabe S. Effects of an antiulcer agent, N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat. Jap J Pharmacol 24:357–361, 1974
Okabe S, Takeuchi K, Nakamura K, Takagi K: Inhibitory effect of L-glutamine on the aspirin-induced gastric lesions in the rat. J Pharm Pharmacol 26:605–611, 1974
Brodie DA, Tate CL, Hooke HF: Aspirin: Intestinal damage in rats. Science 170:183–185, 1970
Davenport HW: Gastric mucosal injury by fatty acid and acetylsalicylic acids. Gastroenterology 46:245–253, 1964
Linder AE: Electrolyte changes in rat stomachs following instillation of acid solutions. Am J Physiol 207:606–612, 1964
Linder AE: Effect of histamine on electrolyte changes in solution instilled in rat stomachs. Am J Physiol 210:1321–1326, 1966
Overholt BF, Brodie DA, Chase BJ: Effect of the vagus nerve and salicylates administration on the permeability characteristics of the rat gastric mucosal barrier. Gastroenterology 56:651–658, 1969
Davenport HW, Warner HA, Code CF: Functional significance of gastric mucosal barrier to sodium. Gastroenterology 47:142–152, 1964
Werther JL, Janowitz HD, Dyck WP: The effect of bile on electrolyte movement across canine gastric antral and fundic mucosa. Gastroenterology 59:691–697, 1970
Chvasta TE, Cooke AR: The effect of several ulcerogenic drugs on the canine gastric mucosal barrier. J Lab Clin Med 79:302–315, 1972
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Okabe, S., Honda, K., Takeuchi, K. et al. Inhibitory effect ofl-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat. Digest Dis Sci 20, 626–631 (1975). https://doi.org/10.1007/BF01071172
Issue Date:
DOI: https://doi.org/10.1007/BF01071172