Abstract
The startle response to intense environmental stimuli is found in most, if not all, animal species. Previous studies have shown that selected rodent strains differ in startle response to an acoustic stimulus, suggesting genetic variability. The current experiment was designed to extend these differences to a wider range of rat strains. Forty-six inbred and outbred rat strains were studied. These strains exhibited differences in both the mean amplitude of the startle response and the rate of habituation to startle stimuli over repeated trials. In addition, there was a significant relationship between these measures. These results suggest that robust phenotypic differences in startle response exist among rat strains. As previous investigations have demonstrated a direct relationship between the startle response and other behavioral end points, the use of strain differences in startle response may be an effective way to determine genetic contributions to specific behavioral responses.
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References
Beitner-Johnson, D., Guitart, X., and Nestler, E. J. (1991). Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine-and cocaine-regulated phosphoproteins.Brain Res. 561:147–150.
Commissaris, R. L., Harrington, G. M., Baginski, T. J., and Altman, H. J. (1988). MR/Har and MNRA/Har Maudsley rat strains: Differences in accoustic startle habituation.Behav. Genet. 18:663–669.
Davis, M. (1986). Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm.Behav. Neurosci. 100:814–824.
Davis, M., Gendelman, D. S., Tischler, M. D., and Gendelman, P. M. (1982). A primary acoustic startle circuit: Lesion and stimulation studies.J. Neurosci. 6:791–805.
George, F. R., and Goldberg, S. R. (1989). Genetic differences in responses to cocaine. In Cloet, D., Asghar, K., and Brown, R. (eds.),Mechanisms in Cocaine Abuse and Toxicity, NIDA Research Monograph Series, U.S. Department of Health and Human Services, Rockville, MD, pp. 239–249.
George, F. R., Porrino, L. J., Ritz, M. C., and Goldberg, S. R. (1991). Inbred rat strain comparisons indicate different sites of action for cocaine and amphetamine locomotor stimulant effects.Psychopharmacology 104:457–462.
Glowa, J. R., Geyer, M. A., Gold, P. W., and Sternberg, E. M. (1992). Differential sensitivity to acoustic startle and corticosterone response in LEW/N and F344/N rats.Neuroendocrinology 56:719–723.
Glowa, J. R. Shaw, A. E., and Riley, A. L. (1993). Cocaine-induced conditioned taste aversions: Comparisons between effects in LEW/N and F344/N rat strains.Psychopharmacology (in press).
Koob, G. F., and Bloom, F. E. (1988). Cellular and molecular mechanisms of drug dependence.Science 242:715–723.
Li T. K., and Lumeng, L. (1984). Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats.Alcohol. Clin. Exp. Res. 8:485–486.
Marks, M. J., Stitzel, J. A., and Collins, A. C. (1989). Genetic influences on nicotine responses.Pharmacol. Biochem. Behav. 33:66–678.
Nestler, E. J. (1992). Molecular mechanisms of drug addiction.J. Neurosci. 12:2439–2450.
Pauly, J. R., Ullman, E. A., and Collins, A. C. (1990). Strain differences in adrenalectomy-induced alterations in nicotine sensitivity in the mouse.Pharmacol. Biochem. Behav. 35:171–179.
Piazza, P. V., Deminiere, J. M., LeMoal, M., and Simon, H. (1989). Factors that predict individual vulnerability to amphetamine self-administration.Science 245:1511–1513.
Rigdon, G. C. (1990). Differential effects of apomorphine on prepulse inhibition of acoustic startle reflex in two rat strains.Psychopharmacology 102:419–421.
Skolnick, P., and Daly, J. (1982). Norepinephrine-sensitive adenylate cyclases in rat brain: Relation to behavior and tyrosine hydroxylase.Science 184:175–177.
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., and Wilder, R. L. (1989a). Inflammatory mediator-induced hypothalamic-pituitaryadrenal axis activation is defective in streptococcal cell wall arthritis susceptible Lewis rats.Proc. Natl. Acad. Sci. USA 86:2374–2378.
Sternberg, E. M., Young, W. S., III; Bernardini, R., Calogero, A. E., Chrousos, G. P., Gold, P. W., and Wilder, R. L. (1989b). A central nervous system defect in biosynthesis of corticotropin-releasing hormone is associated with susceptibility to streptococcal cell wall arthritis in Lewis rats.Proc. Natl. Acad. Sci. USA 86:4771–4775.
Sternberg, E. M., Glowa, J. R., Smith, M. A., Calogero, A. E., Listwak, S. J., Aksentijevich S., Chrousos, G. P., Wilder, R. L., and Gold, P. W. (1992). Corticotropin releasing hormone related behavioral and neuroendocrine responses to stress in Lewis and Fischer rats.Brain Res. 570:54–60.
Suzuki, T., George, F. R., and Meisch, R. A. (1988). Differential establishment and maintenance of oral ethanol reinforced behavior in Lewis and Fisher 344 inbred rat strains.J. Pharmacol. Exp. Ther. 245:164–170.
Trullas, R., and Skolnick, P. (1993). Differences in fear motivated behaviors among inbred mouse strains.Psychopharmacology 111:323–331.
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Glowa, J.R., Hansen, C.T. Differences in response to an acoustic startle stimulus among forty-six rat strains. Behav Genet 24, 79–84 (1994). https://doi.org/10.1007/BF01067931
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DOI: https://doi.org/10.1007/BF01067931