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Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species

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An Erratum to this article was published on 01 December 1986

Abstract

A physiological pharmacokinetic analysis ofcis-dichlorodiammineplatinum(II) (DDP) is presented for the rabbit, dog, and human. The results are compared to a previous analysis for the rat. DDP binds irreversibly to low-molecular weight nucleophiles and macromolecules to form mobile and fixed metabolites at rates which are tissue-specific. The rate constant for the formation of fixed metabolite in plasma, determined by in vitro incubation, ranges from 0.004 to 0.008 min−1.

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Author notes

  1. Franklin G. King

    Present address: Department of Chemical Engineering, North Carolina A&T State University, 27411, Greensboro, North Carolina

  2. Fred F. Farris

    Present address: Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, 58105, Fargo, North Dakota

Authors and Affiliations

  1. Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health, 20892, Bethesda, Maryland

    Franklin G. King, Robert L. Dedrick & Fred F. Farris

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  1. Franklin G. King
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An erratum to this article is available at http://dx.doi.org/10.1007/BF01067969.

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King, F.G., Dedrick, R.L. & Farris, F.F. Physiological pharmacokinetic modeling ofcis-dichlorodiammineplatinum(II) (DDP) in several species. Journal of Pharmacokinetics and Biopharmaceutics 14, 131–155 (1986). https://doi.org/10.1007/BF01065258

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