Abstract
Blood and breast milk samples of 16 women were analyzed for PCBs (polychlorinated biphenyls) and some organochlorine pesticides during eight intervals of a 98 day lactation period. Although a general downward trend in residue levels of blood and breast milk was evident, this trend was interrupted by sporadic increases. Most residues in breast milk showed an apparent increase during the first 30 days of lactation, which was not statistically significant. However, during lactation a statistically significant decrease was observed for the following residues, expressed on a milkfat basis: HCB (hexachlorobenzene), oxychlordane, transnonachlor (1-exo, 2-endo, 3-exo-4,5,6,7,8,8-nonachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene), βHCH (hexachlorocyclohexane),p,p′-DDE andp,p′-DDT. Average milk/blood ratios for PCBs, HCB, oxychlordane(1-exo,2-endo-4,5,6,7,8,8-oc-tachloro-2,3-exo-epoxy 2,3,3a,4,7,7a-hexa-hydro-4,7-methanoindene),p,p′-DDE (2,2-bis-(p-chlorophenyl)- 1, 1-dichloroethylene), dieldrin (1,2,3,4, 10,10-hexachloro-exo-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro- 1,4-endo- exo- 5,8-dimethanonaphthalene) and p,p′-DDT (1,l-bis-(p-chlorophenyl)-2,2,2-trichloroethane) levels were 23, 20, 9, 19, 5 and 30 respectively. Milk/blood ratios for PCB andp,p′-DDE levels remained relatively constant during lactation (coefficient of variation ∼20). Accumulation of residues in infant body fat were theoretically estimated
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References
Bakken AF, Seip M (1976) Insecticides in human breast milk Act Paediatr Scand 65:535–539
Brilliant RB, Van Amburg G, Isbister J, Humphrey H, Wilcox K, Eyster J, Bloomer AW, Price H (1978) Breast milk monitoring to measure Michigan's contamination with polybrominated biphenyls. Lancet 643–646
Curley A, Kimbrough R (1969) Chlorinated hydrocarbon insecticides in plasma and milk of pregnant and lactating women Arch Environ Health 18:156–164
DeBellini Y, Cressely J, Deluzarche A, Hazelmann A (1977) Ot ganochlorine pesticides in human milk (1). Ann Fals Exp Chim 70:567–572
Fomon SJ (1974) Infant nutrition, 2nd edn. Saunders, Philadelphia, 64 pp
Greve PA (1975) Organochloorbestrijdingsmiddelen in moeder melk. In: Verslagen, adviezen en rapporten, Departement van Volksgezondheid, Nederland
Gunther FA (1980) Interpreting pesticide residue data at the ar alytical level. In: Gunther FA, Gunther JD (eds) Residue Reviews, Springer-Verlag, New York, 76:155–171
Jelliffe EFP (1976) Breast-feeding and the mother. In: Ciba Foundation Symp 45, Elsevier/Excerpta Medica/North Holland, Amsterdam, pp 119–143
Kerwick A (1965) Handbook of physiology. American Physio logical Soc, Washington DC 617 pp
Kodama H, Ota H (1980) Transfer of polychlorinated biphenyls in infants from their mothers. Arch Environ Health 35:95–100
Krauthacker B, Alebic-kolbah T, Buntic A, Tkalcevic B, Reiner E (1980) DDT residues in samples of human milk, and in mothers' and cord blood serum, in a continental town in Croatia (Yugoslavia). Int Arch Occup Environ Health 46:267–273
McLeod HA, and Wales PJ (1972) A low temperature cleanup procedure for pesticides and their metabolites in biological samples. J Agric Food Chem 20:624–627
Mes J, Davies DJ (1978) Variation in the polychlorinated biphenyl and organochlorine pesticide residues during human breast feeding and its diurnal pattern. Chemosphere 9:699–706
Mes J (1979a) Isothermal splitless capillary gas chromatography of PCB's using a solid injector. In: Proceedings of the 11 th Workshop on Pesticide Residue Analysis, Ontario Ministry of Agriculture and Food, Guelph, Canada, 22 pp
Mes J, Davies DJ (1979b) Presence of polychlorinated biphenyl and organochlorine pesticide residues and the absence of polychlorinated terphenyls in Canadian human milk samples. Bull Environ Contam Toxicol 21:381–387
Mes J, Davies D, Truelove J (1980a) The determination of polychlorinated biphenyl in small samples of monkey milk and tissues I. Int J Environ Anal Chem 8:89–98
Mes J, Davies DJ, Lau Pui-Yan (1980b) The effect of extraction technique on the fat content, polychlorinated biphenyl level and tri- to octachlorobiphenyl distribution in human milk. Chemosphere 9:763–769
Mes J (1981) Experiences in human milk analysis for halogenated hydrocarbon residues. Int J Environ Anal Chem 9:283–299
Mes J, Davies DJ, Turton D (1982) Polychlorinated biphenyl and other chlorinated hydrocarbon residues in adipose tissue of Canadians. Bull Environ Contam Toxicol 28:97–104
Soos K, Ari L, Bajzath J, Kostyal J (1980) Determination of polychlorinated biphenyl (PCB) and chlorinated hydrocarbon insecticide content in human fatty tissue in Hungary. Egészségtudomany 24:385–393
Wickizer TM, Brilliant LB (1981) Testing for polychlorinated biphenyls in human milk. Pediatr 68:411–415
Yakushiji T, Watanabe I, Kuwabara K, Yoshida S, Hori S, Fukushima S, Kashimoto T, Koyama K, Kunita N (1979) Levels of organochlorine pesticides and polychlorinated biphenyls (PCBs) in mothers' milk collected in Osaka Prefecture from 1969 to 1976. Arch Environ Contam Toxicol 8:59–66
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Mes, J., Doyle, J.A., Adams, B.R. et al. Polychlorinated biphenyls and organochlorine pesticides in milk and blood of Canadian women during lactation. Arch. Environ. Contam. Toxicol. 13, 217–223 (1984). https://doi.org/10.1007/BF01055879
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DOI: https://doi.org/10.1007/BF01055879