Abstract
Chlordane residues were determined in human blood and sebum samples. The residue levels in both types of samples were remarkably increased in pest control operators and in the general population living in an area heavily contaminated with chlordane. The compound with the highest level among the residues in the blood of control subjects was oxychlordane followed bytrans- non- achlor andtrans- chlordane, while in the sebum, the highest levels found was that oftrans-chlordane followed bycis-chlordane andtrans-nonachlor. The sebum residue was similar to technical chlordane in its component pattern, but it largely originated from sources other than simple exogenous contamination. Thus, sebum might be a unique and available sample source for evaluating direct exposure to technical chlordane.
A progressive state of contamination was observed in residents whose homes had been treated with chlordane.
Similar content being viewed by others
References
Barnett JR, Dorough HW (1974) Metabolism of chlordane in rats. J Agric Food Chem 22:612–619
IPCS (1984) Chlordane. International Programme on Chemical Safety, Environmental Health Criteria 34, WHO, Geneva, p 82
NRC Canada (1974) Chlordane:Its effects on Canadian ecosystems and its chemistry. National Research Council, Ottawa, Canada NRCC No. 14094, p 189
Sakai K (1987) Chemicals in the environment. J Environmental Pollution Control (Kogai to Taisaku) 23:106–113
Sovocool GM, Lewis RG, Harless RL, Wilson NK, Zehr RD (1977) Analysis of technical chlordane by gas chromatography/mass spectrometry. Anal Chem 49:734–740
Street JC, Blau SE (1972) Oxychlordane:Accumulation in rat adipose tissue on feeding chlordane isomers or technical chlordane. J Agric Food Chem 20:395–397
Tashiro S, Matsumura F (1977) Metabolic routes ofcis- and trans-chlordane in rats. J Agric Food Chem 25:872–880
— (1978) Metabolism of trans-nonachlor and related chlordane components in rat and man. Arch Environ Contam Toxicol 7:113–127
Tojo Y, Wariishi M, Suzuki Y, Nishiyama K (1986) Quantitation of chlordane residues in mothers' milk. Arch Environ
— (1987) Chlordane and heptachlor termiticides; Cancellation Order. Federal Register 52, 42145 (Nov 3) of chlordane and heptachlor in relation to man and the environment-A further review, 1972–1975. EPA/540, 4-76-005. US Environmental Protection Agency, PB-258-339 Washington, DC
— (1987) Chlordane and heptachlor termiticides; Cancellation Order. Federal Register 52, 42145 (Nov 3)
Wariishi M, Suzuki Y, Okamoto F, Nishiyama K (1984) A sensitive method for the analysis of chlordane residues in human blood. Tokushima J Exp Med 31:41–45
Wariishi M, Suzuki Y, Nishiyama K (1986) Chlordane residues in normal human blood. Bull Environ Contam Toxicol 36:635–643
Yamagishi T, Kaneko S, Miyazaki T, Akiyama K, Horii S (1981) Oxychlordane, trans-nonachlor and cis-nonachlor residues in adipose tissues of dogs and cats collected in the Tokyo area. Bull Environ Contam Toxicol 26:407–412
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wariishi, M., Nishiyama, K. Observations on the progress of chlordane contamination in humans by blood and sebum analysis. Arch. Environ. Contam. Toxicol. 18, 501–507 (1989). https://doi.org/10.1007/BF01055016
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01055016