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Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy

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Abstract

Within vivo 1H-MRS resonances of several metabolites were simultaneously measured in cerebral gliomas and adjacent normal brain. 15 patients with inoperable brain gliomas all histologically verified were monitored with 1H-MRS and MRI before and after radiotherapy. 11 patients were evaluable. 1H-MRS technique evolved from single volume measurements to one dimensional and two dimensional 1H spectroscopic imaging. In all patients N-acetyl-aspartate signals were decreased in tumour areas compared to the normal brain hemisphere. No recovery was seen after radiotherapy. Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas. In 5 patients the choline resonance decreased after radiotherapy, accompanied by a shrinkage of tumour diameter on MRI. Lactate signals were present in high grade and unspecified astrocytomas and absent in most low grade gliomas. In 3 patients the lactate signal disappeared after radiotherapy. These observations indicate the feasibility of 1H-MRS in monitoring metabolic responses on radiotherapy of brain gliomas.

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References

  1. Segebarth CM, Baleriaux DF, Luyten PR, den Hollander JA: Detection of metabolic heterogeneity of human intracranial tumorsin vivo by 1H NMR spectroscopic imaging. Magn Res Med 13: 62–67, 1990

    Google Scholar 

  2. Luyten PR, Marien AJH, Heindel W, van Gerwen PHJ, Herholz K, den Hollander JA, Friedman G, Heiss WD: Metabolic imaging of patients with intracranial tumours 1H MR spectroscopic imaging and PET. Radiology 176: 791–799, 1990

    PubMed  Google Scholar 

  3. Gill SS, Thomas DGT, van Bruggen N, Gadian DG, Peden CJ, Bell JD, Cox IJ, Menon DK, Lies RA, Bryant DJ, Coutts G A: Proton MR spectroscopy of intracranial tumours. In vivo andin vitro studies. J Comp Ass Tomography 14(4): 497–504, 1990

    Google Scholar 

  4. Peeling J, Sutherland G: High-resolution 1H NMR spectroscopy studies of extracts of human cerebral neoplasms. Magnetic Res Med 24: 123–136, 1992

    Google Scholar 

  5. Van Vaals JJ, Bergman AH, van den Boogert HJ, Heerschap A, van der Kogel AJ, Ruifrok ACC, Bernsen HJJA: Non invasivein vivo localized 1H spectroscopy of human astrocytoma implanted in rat brain: regional differences followed in time. NMR in Biomedicine 4: 125–132, 1991

    PubMed  Google Scholar 

  6. Arnold DL, Shoubridge EA, Villemure JH, Feindel W: Proton and phosphorus magnetic resonance spectroscopy of human astrocytomasin vivo. Preliminary observations on tumour grading. NMR in Biomedicine 3 no 4: 184–189, 1990

    PubMed  Google Scholar 

  7. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R, Hamburger C: Non-invasive differentiation of tumors with use of localized H-1 MR spectroscopyin vivo: initial experience in patients with cerebral tumours. Radiology 172: 541–548, 1989

    PubMed  Google Scholar 

  8. Ross BD, Merkle H, Staewen RS, Garwood M: Spatially localized 1H spectroscopy of a rat intracerebral glioma. Soc Magn Reson Med, 8th Ann Meeting 146:1989

  9. Ott D, Ernst T, Henning J: Clinical value of 1H spectroscopy of brain tumorsSoc. Magn Reson Med 9th Ann Meeting 105: 1990a

  10. Alger JR, Frank JA, Bizzi A, Fulham MJ, De Souza BX, Duhaney MO, Inscoe SW, Black JL, van Zijl PCM, Moonen CTW, Di Chiro G: Metabolism of human gliomas: assessment with H-1 spectroscopy and F-18 fluorodeoxyglucose PET. Radiology 177: 633–641, 1990

    PubMed  Google Scholar 

  11. Gadian DG, Porteous R, Gill SS, Small RK, Thomas DGT, Patel P, Bell JD, Van Bruggen N, Kauppinen RA, Williams SR: Metabolites as 1H NMR markers of brain disease. Soc Magn Reson Med, 8th Ann Meeting 487:1989

  12. Miller BL: A review of chemical issues in 1H NMR spectroscopy. N-acetyl I-aspartate, creatine and choline. NMR in Biomedicine 4: 47–52, 1991

    Google Scholar 

  13. Urenjak J, Williams SR, Gadian DG, Noble M: Specific expression of N-acetyl aspartate in neurons, oligodendrocyte type-2 astrocyte progenitors, and immature oligodendrocytesin vitro. J Neurochem 59: 55–61, 1992

    PubMed  Google Scholar 

  14. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R: Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brainin vivo. Magn Res Med 9: 79–93, 1989

    Google Scholar 

  15. Go KG: Cerebral pathophysiology. An integral approach with some emphasis on clinical implications. Elsevier, Amsterdam, 1991

    Google Scholar 

  16. Weinhouse S: Glycolysis, respiration and anomalous gene expression in experimental hepatomas: G.H. A. Clowes memorial lecture. Cancer Res 32: 2007–2016, 1972

    PubMed  Google Scholar 

  17. Kirsch WM, Schultz D, van Buskirk J, Nakane P: Prog Exp Tumor Res 17: 163–191, 1972

    PubMed  Google Scholar 

  18. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R: Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Magn Res Med 9: 126–131, 1989

    Google Scholar 

  19. Klein J, Koppen A, Loffelholz K, Schmitthenner J: Uptake and metabolism of choline by rat brain after acute choline administration. J Neurochemistry 58 no 3: 870–876, 1992

    Google Scholar 

  20. Bourgeois D, Remy C, Lefur Y: Proton spectroscopic imaging: a tool for studying intracerebral tumour models in rat. Magn Res Med 21(1): 10–20, 1991

    Google Scholar 

  21. Cristensen Lour HO, Clausen J, Biering F: Phospholipids and glycolipids of tumours of the central nervous system. J Neurochem 12: 614–627, 1965

    Google Scholar 

  22. Wolleman M: Biochemistry of brain tumours. In: Lajtma A (ed) Handbood of Neurochemistry, Plenium Press 7: 515–535, 1972

  23. Jacobsen HG: Positron emission tomography in oncology. JAMA 259: 2126–2131, 1988

    PubMed  Google Scholar 

  24. Kornblith PL: Metabolic studies of brain tumoursin vivo. In: Salcman M (ed) Neurobiology of Brain Tumours, Williams and Wilkins, 1991

  25. Warburg O: The metabolism of tumours. A. Constable, London 75–327, 1930

  26. Rhodes CG, Wise RJS, Gibbs JM, Frackowiah K, Hatazawa J, Palmer A, Thomas DGT, Jones T:In vitro disturbance of the oxydative metabolism in human cerebral gliomas. Ann Neurol 14: 614–626, 1983

    PubMed  Google Scholar 

  27. Burger PC: Pathologic anatomy and CT correlations in the glioblastoma multiforme. Appl Neurophysiol 46: 180–187, 1983

    PubMed  Google Scholar 

  28. Burger PC, Dubois PJ, Clifford Schold S, Smith KR, Odom GL, Crafts DC, Giangaspero F: Computerized tomographic and pathologic studies of the untreated, quiescent and the recurrent glioblastoma multiforme. J Neurosurg 58: 159–169, 1983

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiotherapy, University Hospital Groningen, The Netherlands

    M. A. A. M. Heesters

  2. Department of Radiology, University Hospital Groningen, The Netherlands

    R. L. Kamman & E. L. Mooyaart

  3. Department of Neurosurgery, University Hospital Groningen, The Netherlands

    K. G. Go

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  1. M. A. A. M. Heesters
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  2. R. L. Kamman
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  3. E. L. Mooyaart
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  4. K. G. Go
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Heesters, M.A.A.M., Kamman, R.L., Mooyaart, E.L. et al. Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. J Neuro-Oncol 17, 27–35 (1993). https://doi.org/10.1007/BF01054271

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