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Effects of allapinine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes

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Abstract

The effects were investigated of allapinine, diterpene alkaloid on ionic currents in voltage-clamped trigeminal neurons and cardiomyocytes isolated from rats. Allapinine application was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence. Potential differences between the mechanisms of antiarrhythmic action of diterpene alkaloids and standard antiarrhythmic substances are examined.

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Authors
  1. A. E. Valeev
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  2. A. N. Verkhratskii
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  3. F. N. Dzhakhangirov
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Additional information

A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Institute of Plant Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Neirofiziologiya, Vol. 22, No. 2, pp. 201–206, March–April, 1990.

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Valeev, A.E., Verkhratskii, A.N. & Dzhakhangirov, F.N. Effects of allapinine on sodium currents in neurons isolated from the rat trigeminal ganglion and cardiomyocytes. Neurophysiology 22, 157–162 (1990). https://doi.org/10.1007/BF01052164

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  • DOI: https://doi.org/10.1007/BF01052164

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