Abstract
Aryl-2 propionic acids such as fenoprofen and ibuprofen, which are anti-inflammatory agents, are synthesized by electrolysing a solution of ArCH(CH3)Cl in the presence of carbon dioxide and a nickel catalyst. The electrolyses are carried out galvanostatically in an undivided cell at a large scale of 50 mmol in 100 ml of solvent (e.g. tetramethylurea). Conversion rates close to 80% and chemical yields up to 85% are achieved. Electrolyses can be performed without catalyst.
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Fauvarque, J.F., Jutand, A. & Francois, M. Nickel catalysed electrosynthesis of anti-inflammatory agents. Part I — Synthesis of aryl-2 propionic acids, under galvanostatic conditions. J Appl Electrochem 18, 109–115 (1988). https://doi.org/10.1007/BF01016213
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DOI: https://doi.org/10.1007/BF01016213