Summary
In the acute anaphylactic as well as histamine shock of guinea pigs an increase of the serum catecholamines was found. Mepyramine doses high enough to abolish the anaphylactic bronchospasm did not prevent the catecholamine release, but reduced it. When the anaphylactic bronchoconstriction was inhibited by mepyramine, mean serum adrenaline concentrations 20 min after antigen were as high as in acute anaphylactic shock without administration of antihistamines; 120 min after antigen no increases was seen. In animals which died in the so-called protracted anaphylactic shock the serum adrenaline concentrations were the highest found at all. The results are discussed in view of the role of catecholamines in anaphylaxis.
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Bernauer, W., Hagedorn, M. & Filipowski, P. Catecholamine release during anaphylactic shock in guinea pigs. Naunyn-Schmiedebergs Arch. Pharmak. 270, 326–334 (1971). https://doi.org/10.1007/BF01002344
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DOI: https://doi.org/10.1007/BF01002344