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Combined immunodeficiency and inborn errors of purine metabolism

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Conclusion

These findings have given us renewed hope of identifying the causes of other inborn immune defects and eventually of curing them. Continued studies may lead to development of better immunosuppressive drugs and to a deeper understanding of the influence of nucleic acid metabolism on immune function.

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Abbreviations

1. ADA:

Adenosine deaminase (EC 3.5.4.4)

2. SCID:

Severe combined immunodeficiency

3. T cell:

Thymus-derived lymphocyte

4. PNP:

Purine-nucleoside phosphorylase (EC 2.4.2.1)

5. ATP:

Adenosine triphosphate

6. Ig:

Immunoglobulin

7. B cell:

Bone marrow-derived lymphocyte

8. AMP:

Adenosine monophosphate

9. ADP:

Adenosine diphosphate

10. HLA:

Human leukocyte group A

11. MLC:

Mixed leukocyte culture

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Authors and Affiliations

  1. Division of Laboratories and Research, New York State Department of Health, Birth Defects and Kidney Disease Institutes, 12201, Albany, New York, USA

    H. J. Meuwissen M. D.

  2. Department of Pediatrics, Albany Medical College, 12208, Albany, New York, USA

    B. Pollara

Authors
  1. H. J. Meuwissen M. D.
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  2. B. Pollara
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Supported in part by Clinical Studies Center Grant No. 2-MO-1-RR-00749-05

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Meuwissen, H.J., Pollara, B. Combined immunodeficiency and inborn errors of purine metabolism. Blut 37, 173–181 (1978). https://doi.org/10.1007/BF00996718

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  • DOI: https://doi.org/10.1007/BF00996718

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