Summary
The cellular composition of the pancreatic islets of juvenile diabetics was studied, using recently developed immunocytochemical methods. B-cells were identified only in juvenile diabetics with a disease of short duration. In chronic juvenile diabetics, the islets which are classically viewed as “atrophic”, were shown to be composed of glucagon- and of somatostatin-cells. Another type of islets which commonly occurs in the pancreas of juvenile diabetics, i. e. the ribbon-like type first described by Cecil in 1911, appeared to be composed almost exclusively of “pancreatic polypeptide” (HPP)-cells. It is suggested that hyperplasia of the HPP-cells in the pancreas of juvenile diabetics results from an atypical type of islet regeneration induced by a severe and prolonged injury to the pancreatic endocrine tissue.
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Gepts, W., De Mey, J. & Marichal-Pipeleers, M. Hyperplasia of “pancreatic polypeptide”-cells in the pancreas of juvenile diabetics. Diabetologia 13, 27–34 (1977). https://doi.org/10.1007/BF00996324
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DOI: https://doi.org/10.1007/BF00996324