Summary
The effect of spontaneous diabetes on plasma lipids during the natural course of the disease was studied in genetically diabetic mice (C57BL/KsJ-db/db). Hyperlipidaemia developed uniformly in all mice studied and was found to be a characteristic part of the diabetic syndrome, as compared to normal littermates. The hyperlipidaemia was characterized by a marked rise in plasma triglyceride levels with age and severity of the disease, increasing from 120 ±6 mg/dl at 5 weeks of age to 400 ± 91 mg/dl at 19 weeks of age. In addition, db/db mice were observed to be hypercholesterolaemic as compared to age-matched normal littermates. The plasma cholesterol levels of diabetic mice were elevated early in the disease, as compared to control mice (200 ± 6 vs. 130 ± 7 mg/dl, respectively), and the mean level remained elevated throughout the period of observation.
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This work was supported by a grant from the USPHS-NIAMDD-AM15,100
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Tuman, R.W., Doisy, R.J. The influence of age on the development of hypertriglyceridaemia and hypercholesterolaemia in genetically diabetic mice. Diabetologia 13, 7–11 (1977). https://doi.org/10.1007/BF00996320
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DOI: https://doi.org/10.1007/BF00996320