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Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors

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Abstract

Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.

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Authors and Affiliations

  1. Institute of Experimental Medicine, Hungarian Academy of Sciences, P.O.B. 67, H-1450, Budapest

    Judit Kapocsi, George T. Somogyi, Nandor Ludvig, Peter Serfozo, Laszlo G. Harsing Jr., Russell J. Woods & E. Sylvester Vizi

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  1. Judit Kapocsi
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  2. George T. Somogyi
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  3. Nandor Ludvig
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  4. Peter Serfozo
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  5. Laszlo G. Harsing Jr.
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  6. Russell J. Woods
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  7. E. Sylvester Vizi
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Special Issue Dedicated to Dr. Abel Lajtha

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Kapocsi, J., Somogyi, G.T., Ludvig, N. et al. Neurochemical evidence for two types of presynaptic alpha2-adrenoceptors. Neurochem Res 12, 141–147 (1987). https://doi.org/10.1007/BF00979530

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