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Acute reduction of brain substance P induced by nicotine

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Abstract

Ten minutes after a single injection of 0.8 mg/kg nicotine SC (free base) the level of substance P-like immunoreactivity (SPLI) was reduced by 61–73% in rat caudate-putamen, nucleus accumbens, and olfactory tubercle, with smaller and not significant reductions in the frontal cortex, substantia nigra, and ventral tegmental area. The nicotinic receptor antagonist mecamylamine (1.0 mg/kg IP) prevented the reductions in SPLI. The rapidity and the degree of the changes in SPLI after nicotine exceed those previously reported for other agents and implicate substance P neurotransmission as a major component of nicotinic action.

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Authors and Affiliations

  1. Institute of Rehabilitation Medicine, NYU Medical Center, New York, NY

    N. E. Naftchi & J. Sleis

  2. Department of Neurology, Mount Sinai School of Medicine, New York, NY

    H. Maker & E. Lapin

  3. Department of Neurology, Beth Israel Medical Center, New York, NY

    H. Maker

  4. Massachusetts Medical Center, Worcester, MA

    S. Leeman

  5. Center for Neurochemistry, The Nathan S. Kline Institute for Psychiatric Research, Ward's Island, New York, 10035, NY

    A. Lajtha

Authors
  1. N. E. Naftchi
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  2. H. Maker
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  3. E. Lapin
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  4. J. Sleis
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  5. A. Lajtha
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  6. S. Leeman
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Naftchi, N.E., Maker, H., Lapin, E. et al. Acute reduction of brain substance P induced by nicotine. Neurochem Res 13, 305–309 (1988). https://doi.org/10.1007/BF00972478

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  • DOI: https://doi.org/10.1007/BF00972478

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