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Interaction of naloxone with the opioid receptor complex in vitro

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Abstract

Previous work from this laboratory suggests that distinct morphine and enkephalin receptors coexist in an opioid receptor complex. In this paper the interaction of naloxone with the receptor complex is studied. The results further strengthens the hypothesis that leucine enkephalin binds poorly to the morphine receptor and that morphine and enkephalin receptors are allosterically coupled.

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Author notes

  1. Richard B. Rothman

    Present address: NIMH, 9000 Rockville Pike, Bldg. 10 Rm 3N256, 20205, Bethesda, Maryland

Authors and Affiliations

  1. Department of Pharmacology, University of Virginia Medical School, 22908, Charlottesville, Virginia

    Richard B. Rothman & Thomas C. Westfall

  2. Department of Pharmacology, St. Louis University School of Medicine, 63104, St. Louis, Mo.

    Richard B. Rothman & Thomas C. Westfall

Authors
  1. Richard B. Rothman
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  2. Thomas C. Westfall
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Rothman, R.B., Westfall, T.C. Interaction of naloxone with the opioid receptor complex in vitro. Neurochem Res 7, 1375–1384 (1982). https://doi.org/10.1007/BF00966066

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  • DOI: https://doi.org/10.1007/BF00966066

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