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Localization of monoamine oxidases A and B in primate brains relative to neuron-specific and non-neuronal enolases

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Abstract

Using serotonin and phenylethylamine deamination as measures of MAO A and MAO B activity respectively, positive correlations were observed between the activities of MAO A and MAO B in different areas of rhesus monkey and human brains. When the activities of MAO A and MAO B were compared with those of neuron-specific enolase and nonneuronal enolase (isozymes which are markers for neurons and glia), a slight but non-significant correlation was observed, suggesting that a simple distribution of MAO A in neurons and MAO B in glia is unlikely. This conclusion is supported by studies using synaptosomes, but contrasts with that from investigations of MAO from peripheral tissues, where experiments indicate that MAO A is predominantly localized in neurones.

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Authors and Affiliations

  1. Clinical Neuropharmacology Branch, National Institute of Mental Health, 20205, Bethesda, Maryland

    Iain C. Campbell, Nancy A. Garrick & Dennis L. Murphy

  2. Clinical Psychobiology Branch, National Institute of Mental Health, 20205, Bethesda, Maryland

    Paul J. Marangos & Alexandra Parma

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  1. Iain C. Campbell
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  4. Nancy A. Garrick
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  5. Dennis L. Murphy
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Campbell, I.C., Marangos, P.J., Parma, A. et al. Localization of monoamine oxidases A and B in primate brains relative to neuron-specific and non-neuronal enolases. Neurochem Res 7, 657–666 (1982). https://doi.org/10.1007/BF00965519

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