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Possible involvement of folate cycle in the pathogenesis of amyotrophic lateral sclerosis

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Abstract

The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous tissue of this disease.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan

    Yoshikazu Yoshino

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  1. Yoshikazu Yoshino
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Dedicated to K. A. C. Elliott on his 80th birthday.

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Yoshino, Y. Possible involvement of folate cycle in the pathogenesis of amyotrophic lateral sclerosis. Neurochem Res 9, 387–391 (1984). https://doi.org/10.1007/BF00963985

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  • DOI: https://doi.org/10.1007/BF00963985

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