Skip to main content
SpringerLink
Log in

Immunodeficient mice xenografted with human lymphoid cells: New models forin vivo studies of human immunobiology and infectious diseases

  • Special Article
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

Abstract

This review article deals with the transfer of human lymphoid or hematopoietic tissues to severely immunodeficient mice to create new small animal models for the study of human biology and disease. The degree of functional reconstitution in the three current models is discussed. SCID mice with human grafts have been infected with human immunodeficiency virus (HIV) to generate a small animal model for AIDS research. Epstein-Barr virus (EBV)-related lymphoproliferative disorders can also be modeled by the transfer of adult peripheral blood mononuclear cells to SCID mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fogh J, Fogh JM, Orfeo T: One hundred and twenty seven cultured tumor cell lines producing tumors in nude mice. J Natl Cancer Inst 59:2216–2221, 1977

    Google Scholar 

  2. Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335:256–259, 1988

    Google Scholar 

  3. McCune JM, Namikawa R, Kaneshima H, Schultz LD, Lieberman M, Weissman IL: The SCID-hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 241:1632–1639, 1988

    Google Scholar 

  4. Kamel-Reid S, Dick JE: Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 242:1706–1709, 1988

    Google Scholar 

  5. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM: Infection of the SCID-hu mouse by HIV-1. Science 242:1684–1687, 1988

    Google Scholar 

  6. Mosier DE, Gulizia RJ, Spector SA, Spector DH, Baird SM, Wilson DB: Human immunodeficiency virus infection of SCID mice reconstituted with human peripheral blood leucocytes (submitted for publication)

  7. Krams SM, Dorschkind K, Gerschwin ME: Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J Exp Med 170:1919–1930, 1989

    Google Scholar 

  8. Bosma GC, Custer RP, Bosma MJ: A severe combined immunodeficiency mutation in the mouse. Nature 301:527–530, 1983

    Google Scholar 

  9. Schuler W, Weiler, IJ, Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ: Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46:963–972, 1986

    Google Scholar 

  10. Dorschkind K, Pollack SB, Bosma MJ, Phillips RA: Natural killer (NK) cells are present in mice with severe combined immunodeficiency (SCID). J Immunol 134:3798–3801, 1985

    Google Scholar 

  11. Andriole GL, Mule JJ, Hansen CT, Linehan WM, Rosenberg SA: Evidence that lymphokine-activated killer cells and natural killer cells are distinct based on an analysis of congenitally immunodeficient mice. J Immunol 135:2911–2913, 1985

    Google Scholar 

  12. Kamel-Reid S, Letarte M, Sirard C, Doedens M, Grunberger T, Fulop G, Freedman MH, Phillips RA, Dick JE: A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science 246:1597–1600, 1989

    Google Scholar 

  13. Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Scientific correspondence. Nature 338:211, 1989

    Google Scholar 

  14. Mosier DE, Gulizia RJ, Wilson DB, Baird SM, Spector SA, Spector DH, Richman DD, Fox RI, Kipps TJ: Elements of the human immune system: Studies of mature lymphoid cells following xenotransplantation to SCID mice.In Progress in Immunology VII, F Melcherset al. (eds). Springer-Verlag, Berlin, 1989, pp 1264–1271

    Google Scholar 

  15. McCune JM, Namikawa R, Shih C-C, Rabin L, Kaneshima H: Suppression of HIV infection in AZT-treated SCID-hu mice. Science 247:564–566, 1990

    Google Scholar 

  16. Koyanagi Y, Miles S, Mitsuyasu, RT, Merrill JE, Vinters HV, Chen ISY: Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236:819–822, 1987

    Google Scholar 

  17. Penn I: Malignant lymphomas in organ transplant recipients. Transplant Proc 13:736–8, 1981

    Google Scholar 

  18. Birx DL, Redfield RR, Tosata G: Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders. N Engl J Med 14:8711–8718, 1986

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunology, Medical Biology Institute, 11077 North Torrey Pines Road, 92037, La Jolla, California

    Donald E. Mosier

Authors
  1. Donald E. Mosier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mosier, D.E. Immunodeficient mice xenografted with human lymphoid cells: New models forin vivo studies of human immunobiology and infectious diseases. J Clin Immunol 10, 185–191 (1990). https://doi.org/10.1007/BF00918650

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00918650

Key words

Search

Navigation