Abstract
In order to assess the genetic etiology of attention deficit hyperactivity disorder (ADHD), the basic regression model for the analysis of selected twin data (DeFries & Fulker, 1985, 1988) was fitted to questionnaire data (DICA: Diagnostic Interview for Children and Adolescents; Herjanic, Campbell, & Reich, 1982) for 37 identical and 37 fraternal twin pairs tested in the Colorado Reading Project. Results of this analysis suggest that ADHD is highly heritable. Moreover, adjusting DICA scores for either IQ or reading performance differences did not substantially change parameter estimates. In future analyses of larger data sets, distinguishing between possible subtypes of attentional problems (e.g., ADD with or without hyperactivity) may facilitate tests of more searching etiological questions.
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References
American Psychiatric Association (1987).Diagnostic and statistical manual (3rd ed.). Washington, DC: Author.
Barkley, R. A. (1990).Attention deficit hyperactivity disorder: A handbook for diagnosis and treatment. New York: Guilford Press.
Biederman, J., Faraone, S. V., Keenan, K., Knee, D., & Tsuang, M. T. (1990). Family-genetic and psychosocial risk factors in DSM-III attention deficit disorder.Journal of the American Academy of Child and Adolescent Psychiatry, 29, 526–533.
Biederman, J., Newcorn, J., and Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders.American Journal of Psychiatry, 48, 564–577.
Cantwell, D. P. (1975). Genetic studies of hyperactive children: Psychiatric illness in biologic and adopting parents. In R. R. Fieve, D. Rosenthal, & H. Brill (Eds.).Genetic research in psychiatry (pp. 273–280). Baltimore: John Hopkins University Press.
Cantwell, D. P., & Baker, L. (1991). Association between attention deficit-hyperactivity disorder and learning disorders.Journal of Learning Disabilities, 24, 88–95.
DeFries, J. C. (1985). Colorado reading project. In D. B. Gray & J. F. Kavanagh (Eds.),Biobehavioral measures of dyslexia (pp. 107–122). Parkton, MD: York Press.
DeFries, J. C., & Fulker, D. W. (1985). Multiple regression analysis of twin data.Behavior Genetics, 15, 467–473.
DeFries, J. C., & Fulker, D. W. (1988). Multiple regression of twin data: Etiology of deviant scores versus individual differences.Acta Geneticae Medicae et Gemellolgiae, 37, 205–216.
DeFries, J. C., & Gillis, J. J. (1991). Etiology of reading deficits in learning disabilities: Quantitative genetic analysis. In J. E. Obrzut and G. W. Hynd (Eds.),Neuropsychological foundations of learning disabilities: A handbook of issues, methods and practice. Orlando, FL: Academic Press.
DeFries, J. C., Gillis, J. J., & Wadsworth, S. J. (in press). Genes and genders: A twin study of reading disability. In A. M. Galaburda (Ed.),The extraordinary brain: Neurobiologic issues in developmental dyslexia. Cambridge, MA: Harvard University Press.
Dunn, L. M., & Markwardt, F. C. (1970).Examiner's manual: Peabody Individual Achievement Test. Circle Pines, MN: American Guidance Service.
Dykman, R. A., & Ackerman, P. T. (1991). Attention deficit disorder and specific reading disability: Separate but often overlapping disorders.Journal of Learning Disabilities, 24, 96–103.
Epstein, M. A., Shaywitz, S. E., Shaywitz, B. A., & Woolston, J. L. (1991). The boundaries of attention deficit disorder.Journal of Learning Disabilities, 24, 78–86.
Felton, R. H., Wood, F. B., Brown, L. B., Campbell, J., & Harter, M. R. (1987). Separate verbal memory and naming deficits in attention deficit disorder and reading disability.Brain and Language, 31, 171–184.
Goodman, R., & Stevenson, J. (1989). A twin study of hyperactivity—II. The aetiological role of genes, family relationships and perinatal adversity.Journal of Child Psychology and Psychiatry, 30, 691–709.
Herjanic, B., Campbell, J., & Reich, W. (1982). Development of a structured psychiatric interview for children: Agreement between child and parent on individual symptoms.Journal of Abnormal Child Psychology, 10, 307–324.
Horn, W. F., Wagner, A. E., & Ianlongo, N. (1989). Sex differences in school-aged children with pervasive attention deficit hyperactivity disorder.Journal of Abnormal Child Psychology, 17, 109–125.
Interagency Committee on Learning Disabilities. (1987).Learning disabilities: A report to the U.S. Congress. Washington, DC: U.S. Government Printing Office.
Lahey, B. B., & Carlson, C. L. (1991). Validity of the diagnostic category of attention deficit disorder without hyperactivity: A review of the literature.Journal of Learning Disabilities, 24, 110–120.
Loney, J. (1987). Hyperactivity and aggression in the diagnosis of attention deficit disorder. In B. B. Lahey & A. E. Kazdin (Eds.),Advances in clinical child psychology (Vol. 10, pp. 99–135). New York: Plenum Press.
Lopez, R. E. (1965). Hyperactivity in twins.Canadian Psychiatric Association Journal, 10, 421–426.
Morrison, J. R., & Stewart, M. A. (1971). A family study of the hyperactive child syndrome.Biological Psychiatry, 3, 189–195.
Nichols, R. C., & Bilbro, W. C. (1966). The diagnosis of twin zygosity.Acta Genetica et Statistica Medico, 16, 265–275.
Plomin, R., DeFries, J. C., & McClearn, G. E. (1990).Behavioral genetics: A primer (2nd ed.). New York: Freeman.
Shaywitz, S. E., & Shaywitz, B. A. (1991). Introduction to the special series on attention deficit disorder.Journal of Learning Disabilities, 24, 68–71.
Stevenson, J. (in press). Evidence for a genetic aetiology in hyperactivity in children.Behavior Genetics.
Wadsworth, S. J., Gillis, J. J., DeFries, J. C., & Fulker, D. W. (1989). Differential genetic aetiology of reading disability as a function of age.The Irish Journal of Psychology, 10, 509–520.
Welner, Z., Reich, W., Herjanic, B., Jung, K. G., & Amado, H. (1987). Reliability, validity, and parent-child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA).Journal of the American Academy of Child and Adolescent Psychiatry, 26, 649–653.
Willerman, L. (1973). Activity level and hyperactivity in twins.Child Development, 44, 288–293.
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This work was supported in part by program project and center grants from NICHD (HD-11681 and HD-27802) to J. C. DeFries. This report was prepared while J. Gillis was supported by NIMH training grant MH-16880, and J. Gilger was supported by a Fellowship in Developmental Psychobiology through the University of Colorado (MH-15442). B. Pennington was also supported by NIMH grants MH-38820 and MH-45916. The invaluable contributions of staff members and families who participated in the Colorado Reading Project are gratefully acknowledged. We also acknowledge the expert editorial assistance of the late Rebecca G. Miles.
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Gillis, J.J., Gilger, J.W., Pennington, B.F. et al. Attention deficit disorder in reading-disabled twins: Evidence for a genetic etiology. J Abnorm Child Psychol 20, 303–315 (1992). https://doi.org/10.1007/BF00916694
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DOI: https://doi.org/10.1007/BF00916694