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Role of Cytokines in Angiogenesis: Turning It On and Off

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

Abstract

The microenvironment surrounding endothelial cells is rich with secreted proteins necessary for regulating the life cycle of a blood vessel. Without these critical cytokines, initiation and growth of new blood vessels would cease and the integrity of existing blood vessels would be diminished. Cytokine-­induced regulation of angiogenesis is critical for normal vessel growth and ischemic tissue repair, but if unchecked may lead to tumor progression and metastasis. In this chapter, we introduce the cytokines that play active roles during the different stages of angiogenesis and discuss their ability to coordinate both pro- and anti-angiogenic outcomes.

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Acknowledgments

Work described in this manuscript was in part supported by National Institute of Health grants HL091983, HL105597, HL095874, HL053354 and HL108795 (R.K.) and NRSA F32 postdoctoral award HL107093 (M.T.).

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Authors and Affiliations

  1. Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL, 60611, USA

    Melissa A. Thal & Raj Kishore Ph.D.

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  1. Melissa A. Thal
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  2. Raj Kishore Ph.D.
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Correspondence to Raj Kishore Ph.D. .

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Editors and Affiliations

  1. Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, 4301 W Markham, Little Rock, 72205, Arkansas, USA

    Jawahar L. Mehta

  2. Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, 351 Tache Avenue, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Thal, M.A., Kishore, R. (2013). Role of Cytokines in Angiogenesis: Turning It On and Off. In: Mehta, J., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5857-9_3

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