Abstract
The experiments described have shown that, whereas the injection of tetanus toxoid (tet) into 8 of 12 control individuals resulted in the appearance of specific anti-tet-IgG antibodies in their plasma, immunization of 14 anergic patients did not elicit an antibody response. This observation was extended to anin vitro system, where cells from four control subjects were shown to secrete anti-tet-IgG antibodies in response to polyclonal activators whereas cells from eight anergic patients did not. It is suggested that this failure of humoral immunity could account for the high risk of bacterial infections in anergy.
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Meakins JL, Pietsch JB, Bubenik O, Kelly RA, Rode H, Gordon J, MacLean LD: Delayed hypersensitivity: Indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 186:241–249, 1977
Meakins JL, Christou NV, Shizgal HM, MacLean LD: Therapeutic approaches to anergy in surgical patients: Surgery and levamisole. Ann Surg 190:286–296, 1979
Pietsch JB, Meakins JL, MacLean LD: The delayed hypersensitivity response: Application in clinical surgery. Surgery 82:349–355, 1977
Rode, HN, Christou NV, Bubenik O, Superina R, Gordon J, Meakins JL, MacLean LD: Lymphocyte function in anergic patients. Clin Exp Immunol 47:155–161, 1982
Rode HN, Christou NV, Gordon J, Meakins JL, MacLean LD: Anergy in surgical patients: Is the failure at the afferent or the efferent limb? Surg Forum 30:41–43, 1979
Zollinger W, Dalrymple JM, Artenstein MS: Analysis of parameters affecting the solid phase radioimmunoassay quantitation of antibody to meningococcal antigens. J Immunol 117:1788–1798, 1976
Stevens RH, Saxon A: Immunoregulation in humans: Control of anti-tetanus toxoid antibody production after booster immunization. J Clin Invest 62:1154–1160, 1978
Fraker PJ, Speck JC: Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro3a, 6a-diphenylglycoluril. Biochem Biophys Res Commun 80:849–857, 1978
Kessler SW: Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: Parameters of the interaction of antibody-antigen complexes with protein A. J Immunol 115:1617–1624, 1975
Kessler SW: Cell membrane antigen isolation with the staphylococcal protein A adsorbent. J Immunol 117:1482–1490, 1976
Dorval G, Wigzell H, Leibold W, Killander D: Analysis of cell-surface markers with staphylococcal protein A: Fluorescence studies on mammalian lymphoid determinants. J Immunol Methods 9:251–266, 1976
Stevens, RH, Saxon, A: Differential synthesis of IgM and IgG anti-tetanus toxoid antibody in vitro following in vivo booster immunization of humans. Cell Immunol 45:142–150, 1979
Forse RA, Christou N, Meakins JL, MacLean LD, Shizgal H: Reliability of skin testing as a measure of nutritional state. Arch Surg 116:1284–1288, 1981
Chandra RK: Cell-mediated immunity in nutritional imbalance. Fed Proc 39:3088–3092, 1980
Stiehm ER: Humoral immunity in malnutrition. Fed Proc 39:3093–3097, 1980
Good RA, West A, Fernandes G: Nutritional modulation of immune responses. Fed Proc 39:3908–3104, 1980
Christou NV, Rode H, Meakins JL: The walk-in anergic. The implication of delayed hypersensitivity (DTH) in true elective surgery. Surg Forum 33:42–43, 1982
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Mazaheri, R., Rode, H.N., Abikar, K. et al. Dysfunction of humoral immunity in anergic surgical patients: Absence of anti-tetanus IgG antibody production. J Clin Immunol 4, 65–70 (1984). https://doi.org/10.1007/BF00915289
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DOI: https://doi.org/10.1007/BF00915289