Abstract
Carrageenin-induced inflammatory rat paw swelling was significantly inhibited by intraperitoneal injection of rat fibrinogcn. Whole-body radioscanning of the rat after intraperitoneal administration of 131I-labeled fibrinogen revealed the accumulation of radiolabeled material in the inflammed rat paw. Resorption studies showed that not more than 4% of the intraperitoneally administered [125I]fibrinogen could be demonstrated in the peripheral blood. Furthermore only 1/3 of this circulating radiolabeled protein was able to take part in clot formation, suggesting that inhibition of edema formation is mediated by fibrinogen-derived split products. This is further supported by the finding that rat fibrinopeptides, released by the action of thrombin, also diminish edema formation both after intracardial and intraperitoneal injection into carrageenin-stimulated rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Scherer, R., A. Morarescu, andG. Ruhenstroth-Bauer. 1975. Die spezifische Wirkung der Plasmaproteine bei der Blutkörperchensenkung.Klin. Wochenschr. 53:265–273.
Scherer, R., andG. Ruhenstroth-Bauer. 1976. Plasma protein profiling: The diagnostic evaluation of disorders in plasma protein composition by a new immunoelectrophoretic method.Clin. Chim. Acta 66:417–433.
Abd-El-Fattah, M., R. Scherer, andG. Ruhenstroth-Bauer. 1976. Application of quantitative two-dimensional immunoelectrophoresis in the study of the acute-phase reaction following injection of the lipid A component of bacterial lipopolysaccharides in rats.J. Mol. Med. 1:211–221.
Rapaport, S. I., andA. Zivelin. 1976. Fibrinogen response to turpentine and endotoxin in busulfan-treated rabbits.Thromb. Haemostasis. 35:693–701.
Scherer, R., M. Abd-El-Fattah, andG. Ruhenstroth-Bauer. 1977. Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systematic acute-phase reaction of the rat.In Perspectives in Inflammation. D. A. Willoughby, J. P. Girond, and G. P. Velo, editors. MTP Press, Lancaster. 437–444.
Hess, S. M., andR. C. Millowy. 1972. Assays for anti-inflammatory agents.In Inflammation. J. H. Lepow and P. A. Ward, editors. Academic Press, New York. 1–12.
Heusser, C., M. Boesman, J. H. Nordin, andH. Isliker. 1973. Effect of chemical and enzymatic radioiodination on in vitro human Clq activities.J. Immunol. 110:820–828.
Scherer, R., I. Simon, M. Abd-El-Fattah, andG. Ruhenstroth-Bauer. 1980. The effect of fibrinopeptides A and B on experimental allergic encephalomyelitis.Clin. Exp. Immunol. 40:49–59.
Richardson, D. L., D. S. Pepper, andA. S. Kay. 1976. Chemotaxis for human monocytes by fibrinogen-derived peptides.Br. J. Haematol. 32:507–513.
McKenzie, R., D. S. Pepper, andA. B. Kay. 1975. The generation of chemotactic activity for human leukocytes by the action of plasmin on human fibrinogen.Thromb. Res. 6:1–8.
Ratnoff, O. D. 1969. Some relationshps among hemostasis, fibrinolytic phenomena, immunity and the inflammatory response.Adv. Immunol. 10:145–227.
DiRosa, M. D. 1972. Biological properties of carrageenin.J. Pharm. Pharmacol. 24:89–102.
Kwaan, H. C., andT. Astrup. 1964. Fibrinolytic activity of reparative connective tissue.J. Pathol. Bacteriol. 87:409–414.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ruhenstroth-Bauer, G., Scherer, R., Hornberger, M. et al. Demonstration of antiinflammatory activity of fibrinogen and fibrinopeptides in rats. Inflammation 5, 343–351 (1981). https://doi.org/10.1007/BF00911098
Issue Date:
DOI: https://doi.org/10.1007/BF00911098