Skip to main content
SpringerLink
Log in

The sensitivity of the mouse testis to the mutagenic action of triethylenemelamine

  • Published:
Zeitschrift für Vererbungslehre Aims and scope Submit manuscript

Summary

The low dose of 0.2 mg/kg TEM allows the production of viable zygotes from the most sensitive stage of spermatogenesis. The frequency of translocations among offspring conceived during this peak period of sterility at 10–14 days p.i. is greater than among those conceived earlier, so that as the fertility of the treated males decreases (i.e. the percentage of dominant lethals increases) the frequency of translocations among their offspring increases. The results provide presumptive evidence that the spermatids are more sensitive to the mutagenic action of TEM than are the mature spermatozoa. A comparison of the incidence of translocations induced by TEM with that induced by X-rays is made and the significance of the occurrence of sterile animals among the F1 is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Auerbach, C., andB. M. Slyzinski: Sensitivity of the Mouse Testis to the mutagenic Action of X-rays. Nature (Lond.)177, 376 (1956).

    Google Scholar 

  • Bock, M., andH. Jackson: The Action of Triethylenemelamine on the Fertility of Male Rats. Brit. J. Pharmacol.12, 6 (1957).

    Google Scholar 

  • Cattanach, B. M.: Induction of Translocations in Mice by Triethylene Melamine. Nature (Lond.)180, 1364 (1957).

    Google Scholar 

  • Cattanach, B. M., andR. G. Edwards: The Effects of Triethyl, enemelamine on the Fertility of Male Mice. Proc. roy. Soc. Edinb. Vol.LXVII, 54–64 (1958).

    Google Scholar 

  • Craig, A. W., B. W. Fox andH. Jackson: Sensitivity of the Spermatogenic Process in the Rat to Radiominetic Drugs and X-rays. Nature (Lond.)181, 353 (1958).

    Google Scholar 

  • Falconer, D. S., B. M. Slyzinski andC. Auerbach: Genetical Effects of Nitrogen Mustard in the House Mouse. J. Genet.51, 81 (1952).

    Google Scholar 

  • Hertwig, P.: Unterschiede in der Entwicklungsfähigkeit von F1 Mäusen nach Röntgen-Bestrahlung von Spermatogonien, fertigen und unfertigen Spermatozoen. Biol. Zbl.58, 273 (1938).

    Google Scholar 

  • Jackson, H., andM. Bock: Effects of Triethylenemelamine on the Fertility of Rats. Nature (Lond.)175, 1037 (1955).

    Google Scholar 

  • Russell, W. L.: Genetic Effects of Radiation in Mammals. Radiation Biology, 1 Chapt. 12, edited byA. Hollaender: New York: McGraw-Hill Comp. 1954.

    Google Scholar 

  • Russell, W. L., L. B. Russell andA. W. Kimball: The Relative Effectiveness of Neutrons from a Nuclear Detonation and from a Cyclotron in inducing Dominant Lethals in the Mouse. Amer. Naturalist89, 269 (1954).

    Google Scholar 

  • Slizinska, H.: Cytological Analysis of Formaldehyde Induced Chromosomal Changes in “Drosophila melanogaster”. Proc. Roy. Soc. Edin. Vol.LXVI, 288–304 (1954).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Animal Genetics, University of Edinburgh, Edinburgh, Schottland

    B. M. Cattanach

Authors
  1. B. M. Cattanach
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cattanach, B.M. The sensitivity of the mouse testis to the mutagenic action of triethylenemelamine. Zeitschrift für Vererbungslehre 90, 1–6 (1959). https://doi.org/10.1007/BF00888569

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00888569

Keywords

Search

Navigation