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ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions

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Abstract

ATP-dependent potassium channels are present at high density in the membranes of heart, skeletal, and smooth muscle and have a lowP open at physiological [ATP]i. The unitary conductance is 15–20 pS at physiological [K+] o , and the channels are highly selective for K+. Certain sulfonylureas are specific blockers, and some K channel openers may also act through these channels. KATP channels are probably regulated through the binding of ATP, which may in turn be regulated through changes in the ADP/ATP ratio or in pHi. There is some evidence for control through G-proteins. The channels have complex kinetics, with multiple open and closed states. The main effect of ATP is to increase occupancy of long-lived closed states. The channels may have a role in the control of excitability and probably act as a route for K+ loss from muscle during activity. In arterial smooth muscle they may act as targets for vasodilators.

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  1. Department of Physiology, University of Leicester, P.O. Box 138, LE1 9HN, Leicester, UK

    N. W. Davies, N. B. Standen & P. R. Stanfield

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Davies, N.W., Standen, N.B. & Stanfield, P.R. ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions. J Bioenerg Biomembr 23, 509–535 (1991). https://doi.org/10.1007/BF00785809

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