Summary
Estrogen receptors (ER) in human gastric carcinomas were examined immunohistochemically using a specific monoclonal antibody to human ER. ER-immunoreactivity (ER-IR) was positive in 30 (27.8%) of the 108 gastric carcinomas examined. ER-IR was located in the nucleus of cancer cells. The incidence of ER-IR positive gastric carcinoma was not significantly different between male and female cases. However, the positive tumour cells were observed in 28 (39.4%) out of the 71 poorly differentiated adenocarcinoma, the incidence being significantly higher than that in well differentiated adenocarcinoma (p<0.01). There was no significant difference in the incidence of ER-IR between scirrhous carcinoma and non-scirrhous poorly differentiated adenocarcinoma. Synchronous expression of ER and epidermal growth factor receptor was found in 8 of the 26 scirrhous carcinomas (30.8%). Patients with ER-IR positive scirrhous gastric carcinomas showed a much worse prognosis than those with ER-IR negative scirrhous carcinomas.
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This work was supported in part by Grant-in Aid for Cancer Research No. 59-15 from the Ministry of Health and Welfare, Japan
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Yokozaki, H., Takekura, N., Takanashi, A. et al. Estrogen receptors in gastric adenocarcinoma: A retrospective immunohistochemical analysis. Vichows Archiv A Pathol Anat 413, 297–302 (1988). https://doi.org/10.1007/BF00783021
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DOI: https://doi.org/10.1007/BF00783021