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Investigation of hormone receptor expression and its prognostic value in endometrial stromal sarcoma

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Abstract

To evaluate the immunohistochemical (IHC) expression of hormone receptors and analyze the prognostic implication of these receptors in patients with endometrial stromal sarcoma (ESS). Fifty-one patients with ESS whose paraffin blocks and pathologic slides, which were obtained after hysterectomy, were available and included in this study. Clinicopathologic data were gathered from patients’ medical records, and IHC staining of hormone receptors was performed using tissue microarrays. Estrogen receptor (ER)-alpha was expressed in 37 patients (72.5%), and strong immunoreactivity was observed in 27 patients (52.9%). However, ER-beta expression was observed in only two patients (3.9%). Progesterone receptor (PR) expression was identified in 36 patients (70.6%), and strong immunoreactivity was found in 26 patients (51%). Androgen receptor (AR) expression was observed in 30 patients (58.8%), and strong immunoreactivity was noted in 14 patients (27.5%). Gonadotropin-releasing hormone receptor (GnRH-R) expression was observed in 49 patients (96.1%), but no patient exhibited strong immunoreactivity. All patients expressed CYP19A1, and 43 patients (84.3%) had strong immunoreactivity. ER-alpha, PR, and AR positivity was associated with significantly better overall survival (OS). No patient with AR positivity died of ESS. When the patients were categorized according to ER-alpha, PR, and AR immunoreactivity, triple-positive ESS had the best OS, and triple-negative ESS was linked to the worst OS. Expression of hormone receptors was associated with favorable survival outcome in ESS. Hormone receptors that showed strong expression deserve further evaluation to clarify their importance as a therapeutic target and predictor of treatment response.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea

    Jeong-Yeol Park, Young-Tak Kim & Joo-Hyun Nam

  2. Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Dongan-gu, Anyang, Republic of Korea

    Min-Hyun Baek

  3. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu, Seoul, Republic of Korea

    Yangsoon Park

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  1. Jeong-Yeol Park
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Correspondence to Jeong-Yeol Park.

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This study was approved by Institutional Review Board of Asan Medical Center, Seoul, Korea.

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The authors declare that they have no conflicts of interest.

Electronic supplementary material

ESM 1

Supplementary Table 1. qRT-PCR results of relative mRNA expression of hormone receptor genes. Supplementary Table 2. Association of expression of hormone receptors with clinic-pathologic characteristics in patients with endometrial stromal sarcoma (n = 51) (DOC 133 kb)

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Park, JY., Baek, MH., Park, Y. et al. Investigation of hormone receptor expression and its prognostic value in endometrial stromal sarcoma. Virchows Arch 473, 61–69 (2018). https://doi.org/10.1007/s00428-018-2358-5

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