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Principles of membrane stability and phase behavior under extreme conditions

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Abstract

Biological membranes consist of a complex assortment of lipids and proteins. The arrangement of the components, particularly in regard to their lateral disposition in the plane of the membrane under physiological conditions, is dependent on the phase behavior of the different membrane lipids and the way that this behavior is modified by interaction with other membrane components and electrolytes in the aqueous medium. Irreversible phase separation of components within the membrane may result from exposure to extreme environmental conditions including temperature, pressure, or electrolyte concentration. The principles underlying the phase-mixing behavior of model membrane systems can be used to provide useful information about the factors that determine the stability of biomembranes under physiological and non-physiological conditions. These data are reviewed and used to predict events that take place when membranes are exposed to environmental stress.

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References

  • Armond, P. A., and Staehelin, L. A. (1979).Proc. Natl. Acad. Sci. USA 76, 1901–1905.

    Google Scholar 

  • Arnold, K., Losche, A., and Gawisch, K. (1981).Biochim. Biophys. Acta 645, 143–148.

    Google Scholar 

  • Bakouche, O., Gerlier, D., Letoffe, J.-M., and Claudy, P. (1986).Biophys. J. 50, 1–4.

    Google Scholar 

  • Blaurock, A. E., and McIntosh, T. J. (1986).Biochemistry 25, 229–305.

    Google Scholar 

  • Blume, A., and Ackermann, Th. (1974).FEBS Lett. 43, 71–74.

    Google Scholar 

  • Brand, J. J., Kirchanski, S. J., and Ramirez-Mitchell, R. (1979).Planta 145, 63–68.

    Google Scholar 

  • Brentel, I., Selstam, E., and Lindblom, G. (1985).Biochim. Biophys. Acta 812, 816–826.

    Google Scholar 

  • Carless, J. M., and Costello, M. J. (1982).Exp. Eye Res. 32, 217–228.

    Google Scholar 

  • Chapman, D., Urbina, J., and Keough, K. M. (1973).J. Biol. Chem. 249, 2512–2518.

    Google Scholar 

  • Crowe, L. M., and Crowe, J. H. (1982).Arch. Biochem. Biophys. 217, 582–587.

    Google Scholar 

  • Cunningham, B. A., Tamura-Lis, W., Lis, L. J., and Quinn, P. J. (1988).J. Colloid Interface Sci. 121, 193–197.

    Google Scholar 

  • Dawson, R. M. C., Irvine, R. F., Bray, J., and Quinn, P. J. (1984).Biochem. Biophys. Res. Commun. 125, 836–842.

    Google Scholar 

  • De Grip, J. N., Drenthe, E. H. S., van Echfeld, C. J. A., de Kruijff, B., and Verkleij, A. J. (1979).Biochim. Biophys. Acta 558, 330–337.

    Google Scholar 

  • De Kruijff, B., and Cullis, P. R. (1980).Biochim. Biophys. Acta 602, 477–490.

    Google Scholar 

  • Ellens, H., Siegel, D., Alford, D., Yeagle, P., Boni, L., Lis, L., Quinn, P. J., and Bentz, J. (1988).Biochemistry (in press).

  • Gabriel, N. E., and Roberts, M. F. (1984).Biochemistry 23, 4011–4015.

    Google Scholar 

  • Gabriel, N. E., and Roberts, M. F. (1986).Biochemistry 25, 2812–2821.

    Google Scholar 

  • Gounaris, K., Mannock, D. A., Sen, A., Brain, A. P. R., Williams, W. P., and Quinn, P. J. (1983a).Biochim. Biophys. Acta 732, 229–242.

    Google Scholar 

  • Gounaris, K., Brain, A. P. R., Quinn, P. J., and Williams, W. P. (1983b).FEBS Lett. 153, 47–52.

    Google Scholar 

  • Gounaris, K., Sen, A., Brain, A. P. R., Quinn, P. J., and Williams, W. P. (1983c).Biochim. Biophys. Acta 728, 129–139.

    Google Scholar 

  • Graham, I., Gagne, J., and Silvius, J. R. (1985).Biochemistry 24, 7123–7131.

    Google Scholar 

  • Gruner, S. M. Rothschild, K. J., and Clark, N. A. (1982).Biophys. J. 39, 241–245.

    Google Scholar 

  • Kouaouci, R., Silvius, J. R., Graham, I., and Pezolet, M. (1985).Biochemistry 24, 7132–7140.

    Google Scholar 

  • Kumar, A., and Gupta, C. M. (1985).Biochemistry 24, 5157–5163.

    Google Scholar 

  • Lee, A. G. (1975).Biochim. Biophys. Acta 413, 11–23.

    Google Scholar 

  • Lee, A. G. (1977).Biochim. Biophys. Acta 472, 285–344.

    Google Scholar 

  • Lee, A. G. (1987).Biochim. Biophys. Acta 507, 433–444.

    Google Scholar 

  • Lewis, R. N. A. H., and McElhaney, R. N. (1985).Biochemistry 24, 2431–2439.

    Google Scholar 

  • Machold, O., Simpson, D. J., and Hoyer-Hansen, G. (1977).Carlsburg Res. Commun. 42, 499–516.

    Google Scholar 

  • Mannock, D. A., Brain, A. P. R., and Williams, W. P. (1985).Biochim. Biophys. Acta 821, 153–164.

    Google Scholar 

  • Mansourian, A. R., and Quinn, P. J. (1986).Biochim. Biophys. Acta 855, 168–178.

    Google Scholar 

  • Mantsch, H. H., Madec, C., Lewis, R. N. A. H., and McElhaney, R. N. (1985).Biochemistry 24, 2440–2446.

    Google Scholar 

  • Masserini, M., and Freire, E. (1986).Biochemistry 25, 1043–1049.

    Google Scholar 

  • Mendelsohn, R., and Koch, C. C. (1980).Biochim. Biophys. Acta 598, 260–271.

    Google Scholar 

  • Quinn, P. J. (1985).Cryobiology 22, 28–46.

    Google Scholar 

  • Quinn, P. J., and Lis, L. J. (1986).Biochim. Biophys. Acta 862, 81–86.

    Google Scholar 

  • Quinn, P. J., and Williams, W. P. (1983).Biochim. Biophys. Acta 737, 223–266.

    Google Scholar 

  • Quinn, P. J., Gounaris, K., and Williams, W. P. (1982).Dev. Plant Biol. 8, 327–330.

    Google Scholar 

  • Rice, D., and Oldfield, E. (1979).Biochemistry 18, 3272–3279.

    Google Scholar 

  • Ruocco, M. J., and Shipley, G. G. (1982).Biochim. Biophys. Acta 684, 59–66.

    Google Scholar 

  • Schmidt, G., and Knoll, W. (1986).Chem. Phys. Lipids 39, 329–339.

    Google Scholar 

  • Sen, A., Williams, W. P., and Quinn, P. J. (1981).Biochim. Biophys. Acta 663, 380–389.

    Google Scholar 

  • Sen, A., Williams, W. P., Brain, A. P. R., and Quinn, P. J. (1982a).Biochim. Biophys. Acta 685, 297–306.

    Google Scholar 

  • Sen, A., Brain, A. P. R., Quinn, P. J., and Williams, W. P. (1982b).Biochim. Biophys. Acta 686, 215–224.

    Google Scholar 

  • Sen, A., Mannock, D. A., Collins, D. J., Quinn, P. J., and Williams, W. P. (1983).Proc. R. Soc. Lond. B 218, 349–364.

    Google Scholar 

  • Shimshick, E. J., and McConnell, H. M. (1973).Biochemistry 12, 2351–2360.

    Google Scholar 

  • Siegel, D. P., Banschback, J., Alford, D., Ellens, H., Lis, L. J., Quinn, P. J., Yeagle, P. L., and Bentz, J. (1988).Biochemistry (in press).

  • Silvius, J. R. (1986).Biochim. Biophys. Acta 857, 217–228.

    Google Scholar 

  • Silvius, J. R., and Gagne, J. (1984a).Biochemistry 23, 3232–3240.

    Google Scholar 

  • Silvius, J. R., and Gagne, J. (1984b)Biochemistry 23, 3241–3247.

    Google Scholar 

  • Silvius, J. R., Lyons, M. J., Yeagle, P. L., and O'Leary, T. J. (1985).Biochemistry 24, 5388–5395.

    Google Scholar 

  • Singer, S. J., and Niclson, G. L. (1972).Science 175, 720–731.

    Google Scholar 

  • Tamura-Lis, W., Reber, E. J., Cunningham, B. A., Collins, J. M., and Lis, L. J. (1986).Chem. Phys. Lipids 39, 119–124.

    Google Scholar 

  • Taraschi, J. F., de Kruijff, B., Verkleij, A. R., and van Echfeld, C., Echfeld, J. A. (1980).Biochim. Biophys. Acta 601, 235–240.

    Google Scholar 

  • Tenchov, B. G. (1985).Prog. Surf. Sci. 20, 273–340.

    Google Scholar 

  • Tsukamoto, Y., Yeki, T., Mitsui, T., Ono, T.-A., and Murata, N. (1980).Biochim. Biophys. Acta 602, 673–675.

    Google Scholar 

  • Van der Steen, A. T. M., de Kruijff, B., and de Grier, J. (1982).Biochim. Biophys. Acta 691, 12–23.

    Google Scholar 

  • Van der Steen, A. T. M., Taraschi, T. F., Voorhout, W. F., and de Kruijff, B. (1983).Biochim. Biophys. Acta 733, 51–64.

    Google Scholar 

  • Van Dijck, P. W. M., Kaper, A. J. Oonk, M. A. J., and de Grier, J. (1977).Biochim. Biophys. Acta 470, 58–67.

    Google Scholar 

  • Van Venetie, R., and Verkleij, A. J. (1982).Biochim. Biophys. Acta 692, 397–405.

    Google Scholar 

  • Verkleij, A. J. (1985).Biochim. Biophys. Acta 779, 43–63.

    Google Scholar 

  • Verwer, W., Ververgaert, P. J. J. T., Leunissen-Bijvelt, J., and Verkleij, A. J. (1979).Biochim. Biophys. Acta 504, 231–234.

    Google Scholar 

  • Viani, P., Cervato, G., Marchesini, S., and Cestaro, B. (1986).Chem. Phys. Lipids 39, 41–51.

    Google Scholar 

  • Wilkinson, D. A., and McIntosh, T. J. (1986).Biochemistry 25, 295–298.

    Google Scholar 

  • Wilkinson, D. A., and Nagle, J. F. (1984).Biochemistry 23, 1538–1541.

    Google Scholar 

Download references

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  1. Department of Biochemistry, King's College London, Campden Hill, W8 7AH, London, United Kingdom

    P. J. Quinn

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Quinn, P.J. Principles of membrane stability and phase behavior under extreme conditions. J Bioenerg Biomembr 21, 3–19 (1989). https://doi.org/10.1007/BF00762209

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  • DOI: https://doi.org/10.1007/BF00762209

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