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Preparation of Drug Liposomes by Thin-Film Hydration and Homogenization

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Liposome-Based Drug Delivery Systems

Part of the book series: Biomaterial Engineering ((BIOENG))

Abstract

Among the methods for liposome preparation, thin-film hydration is one of the most commonly used methods, which will produce heterogeneous multilamellar vesicles (MLVs). Depending on this process, two types of model molecules, including lipophilic drugs and hydrophilic cargoes, have been mainly reported to be incorporated into liposome. The former can be dissolved together with the lipids prior to the formation of thin film, and the latter, such as oligonucleotide-based hydrophilic ingredients, can be dissolved in the hydration mediums, and then passively incorporated into liposomes via hydration procedure. Following the operation of thin-film hydration, two homogenization methods, sonication and extrusion, have been most usually applied to generate liposomes with optimal size and polydispersity, large unilamellar vesicles (LUVs) or small unilamellar vesicles (SUVs). Here, we initially introduce the thin-film hydration and homogenization, and describe the preparation methods for liposomal products entrapping two types of various cargoes above.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China

    Bai Xiang & De-Ying Cao

Authors
  1. Bai Xiang
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  2. De-Ying Cao
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Correspondence to Bai Xiang .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutics, Peking University Department of Pharmaceutics, Beijing, China

    Wan-Liang Lu

  2. Department of Pharmaceutics, Peking University Department of Pharmaceutics, Beijing, China

    Xiang-Rong Qi

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Xiang, B., Cao, DY. (2018). Preparation of Drug Liposomes by Thin-Film Hydration and Homogenization. In: Lu, WL., Qi, XR. (eds) Liposome-Based Drug Delivery Systems. Biomaterial Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49231-4_2-1

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  • DOI: https://doi.org/10.1007/978-3-662-49231-4_2-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-49231-4

  • Online ISBN: 978-3-662-49231-4

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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