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Synthesis of substituted thieno[2,3-d]thiazoles and indolo[3,2-d]thiazoles

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Alkylene-, halo-, and aryl-substituted 2-methylthieno[2,3-d]thiazoles were obtained by the action of phosphorus pentasulfide on the corresponding 2-acetylamino-3-bromo- or 2-acetylamino-3-hydroxythiophenes in an organic solvent with heating. 2-Oximes of halo- and methyl-substituted isatins were converted by reduction and acylation into 2-hydroxy-3-acetylaminoin-doles, from which 2-methylindolo[3,2-d]-thiazoles were obtained by the action of phosphorous pentasulfide with heating in xylene.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 410–417, March, 1987.

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Pinkin, L.D., Dzyubenko, V.G., Abramenko, P.I. et al. Synthesis of substituted thieno[2,3-d]thiazoles and indolo[3,2-d]thiazoles. Chem Heterocycl Compd 23, 345–352 (1987). https://doi.org/10.1007/BF00761998

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  • DOI: https://doi.org/10.1007/BF00761998

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