Summary
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1.
InMytilus andLeucophaea the high-affinity binding site density is significantly lower in old animals than in young animals, whereas the low-affinity site density remains unchanged.
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2.
InMytilus the estimated met-enkephalin and met-enkephalin-Arg6-Phe7 levels are significantly higher in old than in young animals. InLeucophaea only the met-enkephalin level can be determined, and it is also higher in old animals.
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3.
The decrease in the high-affinity binding site density and the corresponding increase in endogenous enkephalin levels suggest the existence of an opioid compensatory mechanism associated with the aging process.
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4.
InMytilus there is a demonstrated decrease with age in intraganglionic dopamine levels in response to applied opiates. In addition, the inhibition of dopaminestimulated adenylate cyclase activity by opiates also decreases in older animals.
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5.
InLeucophaea the sex difference in opioid binding densities diminishes with age.
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Chapman, A., Gonzales, G., Burrowes, W.R. et al. Alterations in high-affinity binding characteristics and levels of opioids in invertebrate ganglia during aging: Evidence for an opioid compensatory mechanism. Cell Mol Neurobiol 4, 143–155 (1984). https://doi.org/10.1007/BF00711001
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DOI: https://doi.org/10.1007/BF00711001