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Hydroxypropyl-β-cyclodextrins: Correlation between the stability of their inclusion complexes with phenolphthalein and the degree of substitution

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Abstract

The stability constants of the inclusion complexes between 2-hydroxypropyl-β-cyclodextrin and phenolphthalein have been found to decrease with increasing degree of substitution; the hydroxypropylation of the primary rim has a relatively higher effect. The change of specific rotations seems to support this finding. The decrease can be explained by the disturbance of the three-site interaction characteristic for the molecular recognition of phenolphthalein by cyclodextrins.

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Authors and Affiliations

  1. Institute of Inorganic and Analytical Chemistry, Eötvös Loránd University, Budapest, Hungary

    Ágnes Buvári-Barcza, Dóra Bodnár-Gyarmathy & Lajos Barcza

Authors
  1. Ágnes Buvári-Barcza
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  2. Dóra Bodnár-Gyarmathy
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  3. Lajos Barcza
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Dedicated to Professor Jószef Szejtli.

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Buvári-Barcza, Á., Bodnár-Gyarmathy, D. & Barcza, L. Hydroxypropyl-β-cyclodextrins: Correlation between the stability of their inclusion complexes with phenolphthalein and the degree of substitution. J Incl Phenom Macrocycl Chem 18, 301–306 (1994). https://doi.org/10.1007/BF00708736

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  • DOI: https://doi.org/10.1007/BF00708736

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