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Necrotizing myelopathy associated with acute lymphoblastic leukemia

Case report and review of literature

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Summary

The clinico-pathological findings are reported of a 16-year-old boy with acute lymphoblastic leukemia who during chemotherapy which included intrathecal Methotrexate developed a transverse cord lesion 5 months before death. Autopsy revealed necrotizing myelopathy of the T8–T10 segments and moderate lymphoblastic infiltration of the cerebrospinal meninges and spinal nerve roots. Neither parenchymal infiltration nor vascular lesions were found. The pathogenesis of this rare lesion associated with acute lymphoblastic leukemia remains obscure.

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Authors and Affiliations

  1. Ludwig Boltzmann-Institut zur Erforschung der Mißbildungen des Nervensystems, Ludwig Boltzmann-Institut für klinische Neurobiologie, Krankenhaus Lainz, Wolkersbergenstraße 1, A-1130, Wien, Austria

    W. Grisold

  2. Ludwig Boltzmann-Institut für Hämatologie und Leukämieforschung, Hanuschkrankenhaus, A-1140, Wien, Austria

    D. Lutz

  3. Pathologisches Institut des Psychiatrischen Krankenhauses der Stadt Wien, A-1140, Wien, Austria

    D. Wolf

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  1. W. Grisold
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  2. D. Lutz
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  3. D. Wolf
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Grisold, W., Lutz, D. & Wolf, D. Necrotizing myelopathy associated with acute lymphoblastic leukemia. Acta Neuropathol 49, 231–235 (1980). https://doi.org/10.1007/BF00707111

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  • DOI: https://doi.org/10.1007/BF00707111

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