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Thermal behavior of ground mixtures of heptakis (2,6-di-O-methyl)-β-cyclodextrin and benzoic acid

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Abstract

Characterization of an inclusion complex prepared from amorphous ground mixtures of heptakis (2,6-di-O-methyl)-β-cyclodextrin (DMβCD) and benzoic acid was carried out by a sealed heating method. The formation of the crystalline inclusion complex and the variation in physicochemical properties of the ground mixture were investigated as a function of heating temperature. On the basis of X-ray diffractometry and Fourier transform infrared spectroscopy, the crystallization of the ground mixture was confirmed to take place at about 135°C. The crystallization temperature was shifted to lower temperatures and the bound molar ratio of benzoic acid to DMβCD increased as the mixing molar ratio of benzoic acid to DMβCD was raised.

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Author notes

  1. Keiji Yamamoto

    Present address: Pharmaceutical Department, Tokyo Women's Medical College, 8-1 Kawadacho, Shinjukuku, 162, Tokyo, Japan

Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Inageku, 263, Chiba, Japan

    Takehisa Hanawa, Etsuo Yonemochi, Toshio Oguchi, Yoshinobu Nakai & Keiji Yamamoto

Authors
  1. Takehisa Hanawa
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  2. Etsuo Yonemochi
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  3. Toshio Oguchi
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  4. Yoshinobu Nakai
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  5. Keiji Yamamoto
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Tsumura & Co., 3586 Yoshiwara, Amimachi, Inashikigun, Ibaraki 300-11, Japan.

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Hanawa, T., Yonemochi, E., Oguchi, T. et al. Thermal behavior of ground mixtures of heptakis (2,6-di-O-methyl)-β-cyclodextrin and benzoic acid. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry 15, 91–101 (1993). https://doi.org/10.1007/BF00706477

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  • DOI: https://doi.org/10.1007/BF00706477

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