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A model for cleavage ofO-glycosidic bonds in glycoproteins

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Abstract

The present work investigated the possibility of cleavage of α-linkages between mannose or galactose and serine/threonine residues by α-mannosidase and α-galactosidase. The study was carried out initially with model synthetic compounds imitating theO-glycosidic bond in glycoproteins, and further with glucoamylase. It was shown that α-mannosidase and α-galactosidase can hydrolyse these linkages after proteolytic digestion of glucosamylase.

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Authors and Affiliations

  1. Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Gatchina, 188 350, St Petersburg, Russia

    Farid M. Ibatullin, Alexander M. Golubev, Leonid M. Firsov & Kirill N. Neustroev

Authors
  1. Farid M. Ibatullin
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  2. Alexander M. Golubev
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  3. Leonid M. Firsov
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  4. Kirill N. Neustroev
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Ibatullin, F.M., Golubev, A.M., Firsov, L.M. et al. A model for cleavage ofO-glycosidic bonds in glycoproteins. Glycoconjugate J 10, 214–218 (1993). https://doi.org/10.1007/BF00702202

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