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Lymphocyte inclusions in the juvenile type of generalized ceroid-lipofuscinosis

An electron microscopic study

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Summary

Peripheral blood lymphocytes exhibiting cytoplasmic vacuoles from eight patients with the juvenile type of generalized ceroid-lipofuscinosis were investigated by electron microscopy. Osmiophilic inclusions could be demonstrated in the vacuoles and occasionally in the cytoplasm proper, revealing a fingerprint-like ultrastructural pattern or a less defined dense granular material, sometimes with an osmiophobic component adjoined. The inclusions are compared with those demonstrated in seven of the cases by earlier investigations of rectal biopsies in a variety of cell types, mainly in nerve cells. Discrimination is attempted between the lymphocyte inclusions and “parallel tubular arrays” regarded as representing a regular lymphocyte constituent.

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  1. Department of Neuropathology and Experimental Brain Research, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Federal Republic of Germany

    Günther Schwendemann

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Schwendemann, G. Lymphocyte inclusions in the juvenile type of generalized ceroid-lipofuscinosis. Acta Neuropathol 36, 327–338 (1976). https://doi.org/10.1007/BF00699638

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