Summary
Demyelination was induced in the superior cerebellar peduncles of weanling mice by the administration of Cuprizone. Remyelination occurred when the animals were replaced on a normal diet. Perineuronal satellite oligodendrocytes in the periventriculat gray were clearly seen to be remyelinating axons. This study demonstrates for the first time the role of these cells in remyelination, and raises the possibility that they may be involved in normal myelination of the central nervous system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blakemore, W. F.: Demyelination of the superior cerebellar peduncle in the mouse induced by Cuprizone. J. Neurol. Sci.20, 63–72 (1973a)
Blakemore, W. F.: Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding Cuprizone. J. Neurol. Sci.20, 73–83 (1973b)
Bunge, R. P.: Glial cells and the central myelin sheath. Physiol. Rev.48, 197–251 (1968)
Herndon, R. M., Price, D. L., Weiner, L. P.: Regeneration of oligodendroglia during recovery from demyelinating disease. Science195, 693–694 (1977)
Hirano, A., Zimmerman, H. M., Levine, S.: Myelin in the central nervous system as observed in experimentally induced edema in the rat. J. Cell Biol.31, 397–411 (1966)
Hyden, H., Lange P. W.: Protein changes in nerve cells related to learning and conditioning. In: The neurosciences second study program (ed. F. O. Schmitt), pp. 278–289. New York: The Rockefeller University Press 1970
King, J. S.: A light and electron microscopic study of perineuronal cells and processes in the rabbit neocortex. Anat. Rec.161, 111 (1968)
Kruger, L., Maxwell, D. S.: Electron microscopy of oligodendrocytes in normal rat cerebrum. Am. J. Anat.118, 411–436 (1966)
Lampert, P.: Electron microscopic studies on ordinary and hyperactive experimental allergic encephalomyelitis. Acta Neuropathol. (Berl.)9, 99–126 (1967)
Ludwin, S. K.: Central nervous system demyelination and remyelination in the mouse. An ultrastructural study of Cuprizone toxicity. Lab. Invest.39, 597–612 (1978)
Mori, S., LeBlond, C. P.: Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats. J. Comp. Neurol.139, 1–30 (1970)
Peters, A.: Oberservations on the connections between myelin sheaths and glial cells in the optic nerve of young rats. J. Anat.98, 125–134 (1964)
Peters, A., Palay, S. L., Webster, H. de F.: The fine structure of the nervous system. The neurons and supporting cells, pp. 233, 248, 264. New York: Harper and Row 1976
Sternberger, N. H., Itoyama, Y., Kies, M. W., Webster, H de F.: Immunocytochemical method to identify basic protein in myelin-forming oligodendrocytes of newborn rat CNS. J. Neurocytol.7, 251–263 (1978a)
Sternberger, N. H., Itoyama, Y., Kies, M. W., Webster, H de F.: Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation. Proc. Natl. Acad. Sci. USA75, 2521–2524 (1978b)
Watson, W. E.: Physiology of neuroglia. Physiol. Rev.54, 245–271 (1974)
Author information
Authors and Affiliations
Additional information
Supported by Grant No. MA 5818 from the Medical Research Council.
Rights and permissions
About this article
Cite this article
Ludwin, S.K. The perineuronal satellite oligodendrocyte. Acta Neuropathol 47, 49–53 (1979). https://doi.org/10.1007/BF00698272
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00698272