Summary
Biopsy tissue from a cerebellar blastomycoma in a 48-year-old man was studied by electron microscopy. The fine structure of the fungi recapitulated that of the yeast forms described in cultures and culture implants. Mycelial forms were not encountered. The yeasts displayed lamellated cell walls and occasional multinucleation. Persistent broad-based budding with complex membranous profiles related to the cell membrane was prominent. The organisms were found within multinucleated giant cells and macrophages which exhibited subplasmalemmal linear densities and occasional desmosomal junctions.
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References
Bakerspigel A (1957) The structure and mode of division of the nuclei of Blastomyces dermatitidis. Can J Microbiol 3:923–936
Buechner HA, Clawson CM (1967) Blastomycosis of the central nervous system. II. A report of nine cases from the Veterans Administration Cooperative Study. Am Rev Respir Dis 95:820–826
Caputo R, Gionotti F (1979) Junctions between histiocytes: role of coated vesicles. J Ultrastruct Res 68:256–264
Carbonell LM (1967) Cell wall changes during the budding process of Paracoccidioides brasiliensis and Blastomyces dermatitidis. J Bacteriol 94:213–223
Carbonell LM, Rodriguez J (1968) Mycelial phase of Paracoccidiodes brasiliensis and Blastomyces dermatitidis: an electron microscope study. J Bacteriol 96:533–543
Collins DN, Edwards MR (1970) Filamentous forms of Blastomyces dermatitidis in mouse lung. Light and electron microscopy. Sabouraudia 7:237–240
Craig WMcK, Carmichael FA, Jr (1938) Blastomycoma of the cerebellum: report of a case. Mayo Clin Proc 13:347–351
Edwards GA, Edwards MR (1960) The intracellular membranes of Blastomyces dermatitidis. Am J Bot 47:622–632
Emmons CW, Binford CH, Utz JP, Kwon-Chung KJ (1977) Medical Mycology, 3rd edn. Lea Febiger, Philadelphia
Fetter BF, Klintworth GK, Hendry WS (1967) Mycoses of the central nervous system. Williams and Wilkins, Baltimore
Garrison RG, Lane JW, Field MF (1970) Ultrastructural changes during the yeastlike to mycelial-phase conversion of Blastomyces dermatitidis and Histoplasma capsulatum. J Bacteriol 101:628–635
Garrison RG, Lane JW, Johnson DR (1973) Ultrastructural studies on the cleistothecium of Ajellomyces dermatitides. Sabouraudia 11:131–136
Garrison RG, Boyd KS (1974) Observations of a naturally occurring lattice array of ribosomes in ultrathin section of Ajellomyces dermatitidis. Mycopathol Mycol Appl 54:335–339
Garrison, RG, Lane JW (1974) The fine structure of the microconidium of Blastomyces dermatitidis. Mycopathol Mycol Appl 52:93–100
Glick AD, Kwon-Chung KJ (1973) Ultrastructural comparison of coils and ascospores of Emmonsiella capsulata and Ajellomyces dermatitidis. Mycologia 65:216–220
Gonyea EF (1978) The spectrum of primary blastomycotic meningitis: a review of central nervous system blastomycosis. Ann Neurol 3:26–39
Lane JW, Garrison RG, Johnson DR (1972) Drug-induced alterations in the ultrastructural organization of Histoplasma capsulatum and Blastomyces dermatitidis. Mycopathol Mycol Appl 48:289–296
Lane JW, Garrison RG (1970) Electronmicroscopy of self-parasitism by Histoplasma capsulatum and Blastomyces dermatitides. Mycopathol Mycol Appl 40:271–276
Leers W-D, Russell NA, Laroye G (1972) Cerebellar abscess due to Blastomyces dermatitides. Can Med Assoc J 107:657–660
Mirra SS, Trombley IK, Miles ML (1979) Toruloma and blastomycoma of the central nervous system: a comparative electron microscopic study. J Neuropathol Exp Neurol 38:333 (abstract)
Mirra SS, Trombley IK, Miles ML (1980) Ultrastructural study of a cerebral toruloma. Acta Neuropathol (Berl) 50:153–157
Miyaji M, Nishimura K (1977) Investigation on dimorphism of Blastomyces dermatitides by agar-implantation method. Mycopathologia 60:73–78
Rippon JW, Zvetina JR, Reyes C (1977) Case report: miliary blastomycosis with cerebral involvement. Mycopathologia 60:121–125
Trombley IK, Mirra SS, Miles ML (1978) An electron microscopic study of central nervous system sarcoidosis. J Neuropathol Exp Neurol 37:702 (abstract)
Waisbren BA, Ullrich D (1962) An isolated blastomycetoma of the posterior cranial fossa treated successfully with surgery and amphotericin B. Am J Med 32:621–624
Yajima K, Fletcher TF, Suzuki K (1977) Subplasmalemmal linear density: a common structure in globoid cells and mesenchymal cells. Acta Neuropathol (Berl) 39:195–200
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Mirra, S.S., Trombley, I.K. & Miles, M.L. Blastomycoma of the cerebellum. Acta Neuropathol 50, 109–114 (1980). https://doi.org/10.1007/BF00692860
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DOI: https://doi.org/10.1007/BF00692860