Summary
Spontaneous neuronal activity was recorded in the cerebral cortex and the CA1 sector of the hippocampus in gerbils during and after 5-min ischemia, produced by bilateral clamping of the common carotid arteries. It was found that spontaneous activity in both cortical and CA1 neurons ceased within 60 s after the onset of ischemia and that it began to reappear 10–20 min after the recirculation. During the next 24 h most CA1 neurons which were recorded showed hyperactivity. This was evident primarily by an increase in spike discharges, whereas recordings from the cerebral cortex were within the preocclusion ranges. On the 2nd day after ischemia, functioning CA1 neurons could not be found, as if they were in a state of functional death, although histological sections showed a general preservation of their cellular structure at that time.
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References
Astrup J (1982) Energy-requiring cell functions in the ischemic brain. J Neurosurg 56:482–497
Griffiths T, Evans MC, Meldrum BS (1982) Intracellular sites of early calcium accumulation in the rat hippocampus during status epilepticus. Neurosci Lett 30:329–334
Harris RJ, Symon L, Branston NM, Bayhan M (1981) Changes in extracellular calcium activity in cerebral ischemia. J Cereb Blood Flow Metab 1:203–209
Hass WK (1981) Beyond cerebral blood flow, metabolism, and ischemic threshold: Examination of the role of calcium in the initiation of cerebral infarction. In: Meyer JS, Lechner H, Reivich M, Ott EO, Aranibar A (eds) Cerebral vascular disease, vol 3. Excerpta Medica, Amsterdam, pp 3–17
Heiss WD, Hayakawa T, Waltz AG (1976) Cortical neuronal function during ischemia. Arch Neurol 33:813–820
Hirsch H, Euler KH, Schneider M (1957) Über die Erholung und Wiederbelebung des Gehirns nach Ischämie bei Normothermie. Pflügers Arch 265:281–313
Hossmann K-A, Kleinhues P (1973) Reversibility of ischemic brain damage. Arch Neurol 29:375–384
Hossmann K-A, Zimmermann V (1974) Resuscitation of the monkey brain after 1 h complete ischemia. I. Physiological and morphological observations. Brain Res 81:59–74
Hossmann K-A (1977) Total ischemia of the brain. In: Zulch JK, Kaufmann W, Hossmann K-A, Hossmann V (eds) Brain and heart infarct. Springer, Berlin Heidelberg New York, pp 107–124
Hossmann K-A, Sakaki S, Zimmermann V (1977) Cation activities in reversible ischemia of the cat brain. Stroke 8:77–81
Li CL, Jasper H (1953) Microelectrode studies of the electrical activity of the cerebral cortex in the cat. J Physiol 121:117–140
Loskota WJ, Lomax P, Rich ST (1974) The gerbil as a model for the study of the epilepsies. Epilepsia 15:109–119
Meldrum BS (1981) Metabolic effects of prolonged epileptic seizures and the causation of epileptic brain damage. In: Rose FC (ed) Metabolic disorders of the nervous system. Pitman, London, pp 175–187
Schwarzkroin PA, Prince DA (1978) Cellular and field potential properties of epileptogenic hippocampal slices. Brain Res 147:117–130
Siesjö BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metab 1:155–185
Suzuki R, Yamaguchi T, Kirino T, Orzi F, Klatzo I (1983) The effects of 5-minute ischemia in Mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes. Acta Neuropathol (Berl) 60:207–216
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Suzuki, R., Yamaguchi, T., Li, CL. et al. The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus. Acta Neuropathol 60, 217–222 (1983). https://doi.org/10.1007/BF00691869
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DOI: https://doi.org/10.1007/BF00691869