Summary
The occurrence of cerebral and cerebellar microgyria in a case of intrauterine infection possibly due to Toxoplasma gondii is reported. A few aspects of two additional micropolygyric brains are briefly reviewed. The deep neuronal lamina in the 4-layered type of cerebral micropolygyria seems to be the equivalent of the normal isocortical infragranular stratum rather than an ectopic subcortical structure. The micropolygyric second layer seems to represent the supragranular and sometimes also the granular laminae. It is suggested that cerebellar microgyria is probably the result of a pathological process involving the external granular layer. Extensive subpial and extrapial gliosis as well as ectopic neurons and myelinated fibers in the meninges were a prominent feature in all three brains. In the main case peculiar multinucleated cells, probably neurons, were found in some areas of the cerebral cortex.
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References
Angevine, J. B., Sidman, R. L.: Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse. Nature (Lond.)192, 766–768 (1961).
Berry, M., Eayrs, J. T.: Histogenesis of the cerebral cortex. Nature (Lond.)197, 984–985 (1963).
—, Rogers, A. W.: The migration of neuroblasts in the developing cerebral cortex. J. Anat. (Lond.)99, 691–709 (1965).
Bielschowsky, M.: Über die Oberflächengestaltung des Großhirnmantels bei Pachygyrie, Mikrogyrie und bei normaler Entwicklung. J. Psychol. Neurol. (Lpz.)30, 29–76 (1923/24).
Crome, L.: Microgyria. J. Path. Bact.64, 479–495 (1952).
— Pachygyria. J. Path. Bact.71, 335–352 (1956).
— Stern, J.: The pathology of mental retardation, p. 113. London: J. & A. Churchill Ltd. 1967.
Ebels, E. J.: The influence of age upon the effect of early postnatal x-irradiation on the development of the cerebellar cortex in rats. Acta neuropath. (Berl.)15, 298–307 (1970).
Margolis, G., Kilham, L.: Virus induced cerebellar hypoplasia. Res. Publ. Ass. Res. nerv. ment. Dis.44, 113–145 (1968).
Phemister, R. D., Shively, J. N., Young, S.: The effects of gamma irradiation on the postnatally developing canine cerebellar cortex. I. Effects of single sublethal exposure. J. Neuropath. exp. Neurol.28, 119–127 (1969a).
——— The effects of gamma irradiation on the postnatally developing canine cerebellar cortex. II. Sequential histogenesis on radiation induced changes. J. Neuropath. exp. Neurol.28, 128–138 (1969b).
Poliakov, G. I., cited by P. Rakić and R. L. Sidman: J. Neuropath. exp. Neurol.27, 274 (1968).
Rakié, P., Sidman, R. L.: Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans. J. comp. Neurol.139, 473–500 (1970).
Tilney, F.: Behaviour in its relation to the development of the brain. Part II. Correlation between the development of the brain and behaviour in the albino rat from embryonic states to maturity. Bull. Neurol. Inst. N. Y.3, 252–258 (1933/34).
Wyatt, J. A., Pollard, A. C.: Recurrent transient hyperglycaemia associated with collapse in identical twins. Proc. roy. Soc. Med.58, 690–692 (1965).
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de León, G.A. Observations on cerebral and cerebellar microgyria. Acta Neuropathol 20, 278–287 (1972). https://doi.org/10.1007/BF00691746
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DOI: https://doi.org/10.1007/BF00691746