Summary
GAG electrophoretic pattern and concentration have been studied in 38 human cerebral tumors and in specimens of normal nervous tissue. Gray matter had higher total GAG concentration and higher CA to HA ratio than white matter. In both, DS was present in very small amount whereas HS represented 15% of GAGs. All benign gliomas displayed the same electrophoretic pattern and contained more GAGs than normal nervous tissue. Dermatan sulfate was detected in malignant gliomas, as well as in other oncotypes, due to their mesodermic component. Ependymomas were particularly rich in HS and meningiomas were poor in HA.
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Supported by CNR Grants N. 81.01462.96 and N. 81.01307.96 (Control of neoplastic growth)
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Bertolotto, A., Giordana, M.T., Magrassi, M.L. et al. Glycosaminoglycans (GASs) in human cerebral tumors. Acta Neuropathol 58, 115–119 (1982). https://doi.org/10.1007/BF00691651
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DOI: https://doi.org/10.1007/BF00691651