Summary
Two cases of sarcoid neuropathy were diagnosed by histological examination of muscle and peripheral nerve biopsies. The epineurium of the first patient showed a few sarcoid granulomas surrounding and invading the wall of an arteriole, and in some arterioles there were sites of fibrinoid necrosis. Sarcoid granulomas encroached on the walls of arterioles in the epineurium of the second patient. Ultrastructural examination showed severe alteration of nerve fibres in the first case and only a few altered fibres in the second. Damage to nerve fibres in these cases depended mainly on the degree of arteriolar wall involvement.
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Vital, C., Aubertin, J., Ragnault, J.M. et al. Sarcoidosis of the peripheral nerve: A histological and ultrastructural study of two cases. Acta Neuropathol 58, 111–114 (1982). https://doi.org/10.1007/BF00691650
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DOI: https://doi.org/10.1007/BF00691650