Summary
Pregnant rats received a single administration of 0.5, 1.0, or 2.0 mg/kg of cadmium on day 18 or 20 or gestation Maternal animals were killed on day 21 and samples of the caudate nucleus from fetal brains were examined using the transmission electron microscope. A 2.0 mg/kg dose of cadmium administered to maternal rats on day 20 of gestation caused the formation of vacuoles in the endothelial cells of capilaries in the fetal brain. Significant endothelial cell vacuolization was not observed in the brain of fetuses from other treatment groups. The vacuoles occurred singly, were spherical in shape, were located adjacent to the intercellular junctions and caused focal distortion of the endothelial cell. Vacuoles were the only ultrastructural alteration observed in the caudate nucleus of fetal brains.
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References
Barr, M.: Teratogenicity of cadmium chloride in 2 stocks of Wistar rats. Teratology7, 237–242 (1973)
Chang, L., Reuhl, K., Spyker, J.: Degenerative changes in developing nervous system as a result of in utero exposure to methylmercury. Environ. Res.14, 414–423 (1977)
Donahue, S.: Relationship between fine structure and function of blood vessels in CNS of rabbit fetuses. Am. J. Anat.115, 17–26 (1964)
Gabbiani, G.: Action of cadmium chloride on sensory ganglia. Experientia22, 261–262 (1966)
Gabbiani, G., Baic, D., Deziel, C.: Toxicity of cadmium for the CNS. Exp. Neurol.18, 154–160 (1967)
Gabbiani, G., Badonnell, M., Mathewson, S., Ryan, G.: Acute cadmium intoxication: early selective lesions of endothelial clefts. Lab. Invest.30, 686–695 (1974)
Hannah, R., Nathaniel, J.: Postnatal development of blood vessels in substantia gelatinosa of rat cervical cord — an ultrastructural study. Anat. Rec.178, 691–710 (1974)
Ishizu, S., Minami, M., Suzuki, A., Yamado, M., Sato, M., Yamura, K.: An experimental study of teratogenic effect of cadmium. Ind. Health11, 127–139 (1973)
Michaelson, I.: Effects of inorganic lead on RNA, DNA and protein content in developing neonatal rat brain. Toxicol. Appl. Pharmacol.26, 539–548 (1973)
Mulvihill, J., Gamm, S., Ferm, V.: Facial formation in normal and cadmium treated rats. J. Embryol. Exp. Morphol.24, 393–403 (1970)
Omori, Y., Takanaka, A., Onida, K., Nakura, S., Urakubo, G., Hasegawa, A.: Studies on the fate of poisonous metals in experimental animals; III. Distribution and transferance of cadmium-115m in pregnant rat and fetus. J. Food Hyg. Soc. Japan16, 271–274 (1975)
Rohrer, S., Shaw, S., Born, G., Vetter, R.: Maternal distribution and placental transfer of cadmium in zinc deficient rats. Bull. Environ. Contam. Toxicol.19, 556–563 (1978)
Schlaepfer, W.: Sequential study of endothelial changes in acute cadmium intoxication. Lab. Invest.25, 556–564 (1971)
Wolkowski, R.: Differential cadmium induced embryotoxicity in two inbred strains of mice. Teratology10, 243–262 (1974)
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Rohrer, S.R., Shaw, S.M. & Lamar, C.H. Cadmium induced endothelial cell alterations in the fetal brain from prenatal exposure. Acta Neuropathol 44, 147–149 (1978). https://doi.org/10.1007/BF00691482
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DOI: https://doi.org/10.1007/BF00691482