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The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

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Summary

Ia antigen, encoded within the major histocompatibility complex, plays an important role in the activation of T lymphocytes. Since experimental allergic encephalitis is an essentially T cell-mediated disease, Ia antigen in the central nervous system (CNS) may be pathogenetically relevant. The occurrence of Ia antigen in the CNS of normal rats and of rats with experimental allergic encephalitis was studied by light and electron microscope immunocytochemistry using the monoclonal anti-Ia antibodies Ox 4 and Ox 6. In normal, unsensitized animals a distict population of stellate cells in the meninges and some perivascular mononuclear cells in the nervous tissue carried Ia antigen. In rats with experimental allergic encephalitis a dramatic increase of Ia-positive cells was found. In addition to the positive cells found in normal animals, monocytes, macrophages and many lymphocytes in the meningeal perivascular and parenchymal inflammatory infiltrates as well as “activated microglia” stained for Ia antigen. We did not find evidence for Ia expression on endothelial cells, astrocytes or other components of the CNS in either normal or diseased rats.

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Authors and Affiliations

  1. Institute of Brain Research, Austrian Academy of Sciences, Vienna, Austria

    K. Vass & H. Lassmann

  2. Clinical Research Unit for Multiple Sclerosis, Max-Planck-Society, D-8700, Würzburg, Federal Republic of Germany

    H. Wekerle

  3. New York State Institute for Basic Research in Developmental Disabilities, New York, USA

    H. M. Wisniewski

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  1. K. Vass
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  2. H. Lassmann
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  3. H. Wekerle
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  4. H. M. Wisniewski
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Vass, K., Lassmann, H., Wekerle, H. et al. The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol 70, 149–160 (1986). https://doi.org/10.1007/BF00691433

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  • DOI: https://doi.org/10.1007/BF00691433

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