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Mitochondrial alterations in the spinal ganglion neurons in ageing rats

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Summary

An ultrastructural study of the mitochondria was performed in the 3-, 24-, and 32-month-old rats. Accumulation of “unusual” substances or structures was the most striking characteristic in senescent neuron mitochondria. Tubular or filamentous inclusions, modifications in matrix density, deposit of glycogen particles and electron-dense globules were observed. The various nature of these alterations and their different situation in the cristae or in the matrix, suggested that they could be the result of some specific xidative metabolism dysfunctions associated with ageing.

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Authors and Affiliations

  1. Unité de Morphologie Animale, Université Catholique de Louvain, Place Croix du Sud, 5, B-1348, Louvain La Neuve, Belgium

    J. Vanneste & Ph. van den Bosch de Aguilar

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  1. J. Vanneste
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  2. Ph. van den Bosch de Aguilar
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This work was performed with grants from the ‘Fonds Interuniversitaire pour ‘Etude des Processus du Vieillissement’ at Montignies-le-Tilleul

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Vanneste, J., van den Bosch de Aguilar, P. Mitochondrial alterations in the spinal ganglion neurons in ageing rats. Acta Neuropathol 54, 83–87 (1981). https://doi.org/10.1007/BF00691335

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  • DOI: https://doi.org/10.1007/BF00691335

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