Summary
In a patient with systemic and nervous system IBS, the CSF cells were investigated by light and electron microscopy. An IBS of the B-cell type was identified in the CSF which proved, at both morphological levels, to be identical to that recorded in IBS in lymphoid tissue with regard to the malignant cell types and the absence of surface specialization. In contrast, unusual macrophages were observed in the CSF instead of the reticular elements associated with IBS in lymph nodes which present desmosomes. They demonstrated both phagocytosis and emperipolesis and also displayed autodesmosomes. The CSF phagocytes are discussed in relationship with the phagocytes described in the brain with malignant lymphoma.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Domagala W, Emeson EE, Greenwald E, Koss LG (1977) A scanning electron-microscopic study of B-cell lymphosarcoma cells in CSF. Cancer 40:716–720
Guseo A (1976) Morphological signs as indications of functions of cells in the CSE. J Neurol 212:159–170
Henry K (1975) Electron microscopy in the non-Hodkin's lymphomata. Br J Cancer [Suppl II] 31:73–93
Hirano A (1975) A comparison of the fine structure of malignant lymphoma and other neoplasms in the brain. Acta Neuropathol (Berl) [Suppl] 6:141–145
Jellinger K, Radaszkiewicz Th (1976) Involvement of the central nervous system in malignant lymphomas. Virchows Arch A [Pathol Anat] 370:345–362
Jellinger K, Slowik F, Sluga E (1979) Primary intracranial malignant lymphomas. A fine structural cytochemical and CSF immunological study. Clin Neurol Neurosurg 81:173–184
Lennert K (1978) Malignant lymphoma other than Hodgkin. Springer, Berlin Heidelberg New York
Lennert K, Niedorf HR (1969) Nachweis von desmosomal verknüpften Reticulumzellen im follikulären Lymphom (Brill symmers). Virchows Arch B [Zellpathol] 4:148–150
Lennert K, Stein H, Kaiserling E (1975) Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer [Suppl II] 31:29–43
Lukes RJ, Collins RD (1975) New approaches to the classification of the lymphomata. Br J Cancer [Suppl II] 31:1–28
Matsuda M, McMurria H, Van Hale P, Miller CA (1981) CSF findings in primary lymphoma of the CNS. Arch Neurol 38:397
Oehmichen M, Gärtner H-V, Knittel-Jung U (1977) T-cell type immunoblastic sarcoma diagnosed primarily by CSF cell membrane features. Klin Wochenschr 55:37–40
Parker JW, Taylor CR, Pattengale PK, Royston I, Tindle BH, Cain MJ, Lukes RJ (1978) Morphologic and cytochemical comparison of human lymphoblastoid T-cell and B-cell lines: Light and electron microscopy. J Natl Cancer Inst 60:59–68
Said JW, Pinkus GS (1980) Immunoblastic sarcoma of the T-cell type. An ultrastructural study of five cases. Am J Pathol 101:515–526
Shamoto M (1981) Emperipolesis of hemapoietic cells in myelocytic leukemia. Electron-microscopic and phase contrast-microscopic studies. Virchows Arch B [Cell Pathol] 35:283–290
Taylor CR, Russell R, Lukes RJ, Davis RL (1978) An immunohistological study of immunoglobulin content of primary CNS lymphomas. Cancer 41:2197–2205
Wollner N, Burchenal JH, Lieberman PH, Exelby P, D'Angio G, Murphy ML (1976) Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy. Cancer 37:123–134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pelc, S., Fondu, P., Otten, J. et al. Immunoblastic sarcoma of the B-cell type in the CSF light- and electronmicroscopic study of the malignant cells and unusual macrophages. Acta Neuropathol 55, 289–292 (1981). https://doi.org/10.1007/BF00690992
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00690992