Summary
The physical and chemical properties of the lipofuscin pigment have been studied in the neurons of C57 BL/10 mice of different ages. The results indicated the presence of two types of lipofuscin with different physical and chemical properties. The properties of these two types of lipofuscin have been discussed. It appears that the two types of lipofuscin found in young and old mice differ in their distribution, stainability, solubility, enzymatic activity, and fluorescence properties. It is suggested that these represent early and late stages in lipofuscin formation of the neurons. The pigment observed in animals deprived of Vitamin E was atypical in nature and did not conform to either of the types mentioned above.
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Publication No. 1017 from the Basic Health Sciences Division of Emory University. Supported by Grant No. HD-04188 from the U.S. Public Health Service.
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Nandy, K. Properties of neuronal lipofuscin pigment in mice. Acta Neuropathol 19, 25–32 (1971). https://doi.org/10.1007/BF00690951
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DOI: https://doi.org/10.1007/BF00690951